{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T12:48:54Z","timestamp":1770900534733,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":2860,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2001,4]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>We studied the effects of the novel noradrenaline and serotonin (5\u2010HT) reuptake inhibitor sibutramine on feeding and body weight in a rat model of dietary obesity, and whether it interacts with hypothalamic neuropeptide Y (NPY) neurones.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Chow\u2010fed and dietary\u2010obese (DIO) male Wistar rats were given sibutramine (3\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup> day<jats:sup>\u22121<\/jats:sup> p.o.) or deionized water for 21 days.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Sibutramine decreased food intake throughout the treatment period in both dietary\u2010obese rats (<jats:italic>P<\/jats:italic>&lt;0.0001) and lean rats (<jats:italic>P<\/jats:italic>&lt;0.0001). Weight gain was reduced so that final body weight was 10% lower in dietary\u2010obese (<jats:italic>P<\/jats:italic>&lt;0.005) and 8% lower in lean (<jats:italic>P<\/jats:italic>&lt;0.05) rats <jats:italic>versus<\/jats:italic> their untreated controls. Plasma leptin concentration was lower in sibutramine\u2010treated dietary\u2010obese rats (<jats:italic>P<\/jats:italic>&lt;0.05), and in treated lean rats (<jats:italic>P<\/jats:italic>&lt;0.05). Using the homeostasis model assessment (HOMA) as a measure of insulin resistance, untreated DIO rats were significantly more insulin resistant than controls (<jats:italic>P<\/jats:italic>&lt;0.005), and this was corrected by sibutramine treatment (<jats:italic>P<\/jats:italic>&lt;0.05). Neither hypothalamic NPY mRNA nor NPY peptide levels in a number of hypothalamic nuclei were significantly altered by sibutramine compared to untreated controls.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The hypophagic and anti\u2010obesity effects of sibutramine in dietary\u2010obese Wistar rats appear not to be mediated by inhibition of ARC NPY neurones.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2001) <jats:bold>132<\/jats:bold>, 1898\u20131904; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0704030\">10.1038\/sj.bjp.0704030<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0704030","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T21:23:30Z","timestamp":1106947410000},"page":"1898-1904","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Sibutramine reduces feeding, body fat and improves insulin resistance in dietary\u2010obese male Wistar rats independently of hypothalamic neuropeptide Y"],"prefix":"10.1111","volume":"132","author":[{"given":"Michael","family":"Brown","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Bing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"King","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucy","family":"Pickavance","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Heal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Wilding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)00351-X"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853899608999066"},{"key":"e_1_2_6_4_1","first-page":"R1765","article-title":"Neuropeptide Y in hypothalamic paraventricular nucleus: a center coordinating energy metabolism","volume":"266","author":"BILLINGTON C.J.","year":"1994","journal-title":"Am. 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