{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:36:02Z","timestamp":1770078962552,"version":"3.49.0"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":2799,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2001,6]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Chronic administration of erythropoietin (EPO) is often associated with hypertension in animals and humans. The aim of this study was to estimate whether 1\u2010week treatment with EPO can affect the vascular endothelial function.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Rabbits were given with EPO (400\u2003iu\u2003kg<jats:sup>\u22121<\/jats:sup> s.c.) or saline each other day for 1 week. Hypotensive responses to intravenously given acetylcholine (ACh), endothelium\u2010independent nitric oxide donors (NOC7, nitroprusside and nitroglycerin) and prostaglandin I<jats:sub>2<\/jats:sub> were tested before and after administration of N<jats:sup>G<\/jats:sup>\u2010nitro\u2010<jats:sc>L<\/jats:sc>\u2010arginine methyl ester (<jats:sc>L<\/jats:sc>\u2010NAME), a specific nitric oxide synthase inhibitor, under pentobarbitone anaesthesia.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Blood haemoglobin concentration in EPO group was significantly higher than that in control group, whereas baseline values of aortic pressure, heart rate and femoral vascular resistance were similar. The dose of ACh (172\u2003ng\u2003kg<jats:sup>\u22121<\/jats:sup>) requiring for a 15\u2003mmHg hypotension from the baseline in EPO group was apparently higher than that (55\u2003ng\u2003kg<jats:sup>\u22121<\/jats:sup>) in control group. On the contrary, hypotensive responses to NOC7, nitroprusside, nitroglycerin and prostaglandin I<jats:sub>2<\/jats:sub> were comparable between two groups. The extent of ACh\u2010induced hypotension did not correlate with haemoglobin concentration.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p><jats:sc>L<\/jats:sc>\u2010NAME significantly inhibited the ACh\u2010induced vasodilating response in control group but did not in EPO group.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In another set of rabbits, the same treatment with EPO also decreased vasodilating responses to carbachol, bradykinin and substance P besides ACh as compared with control group.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These results indicate that 1\u2010week treatment with EPO selectively attenuates depressor responses to endothelium\u2010dependent vasodilators in anaesthetized rabbits, most likely due to inhibition of endothelial nitric oxide synthase.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2001) <jats:bold>133<\/jats:bold>, 395\u2013405; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0704083\">10.1038\/sj.bjp.0704083<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0704083","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T21:27:50Z","timestamp":1106947670000},"page":"395-405","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Effect of 1\u2010week treatment with erythropoietin on the vascular endothelial function in anaesthetized rabbits"],"prefix":"10.1111","volume":"133","author":[{"given":"Katsuhiko","family":"Noguchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Yamashiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiro","family":"Matsuzaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayuko","family":"Sakanashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Nakasone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanako","family":"Miyagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matao","family":"Sakanashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"351","article-title":"Organic nitrate esters: Clinical use and mechanisms of actions","volume":"43","author":"AHLNER J.","year":"1991","journal-title":"Pharmacol. 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