{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T10:26:43Z","timestamp":1760264803361},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":2799,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2001,6]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>The role of selectins in neutrophil emigration in response to the CXC chemokines KC and MIP\u20102 was investigated in wild type and P\u2010selectin deficient mice.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Intrapleural injection of KC or MIP\u20102 induced a rapid and specific neutrophil accumulation. Emigration 2\u2003h after KC or MIP\u20102 was reduced 83\u2003\u2013\u200388% by anti\u2010L\u2010selectin mAb and 53\u2003\u2013\u200363% by anti\u2010P\u2010selectin mAb. Co\u2010administration of anti\u2010L\u2010 and P\u2010selectin mAbs abolished neutrophil migration induced by either chemokine.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>An anti\u2010E\u2010selectin mAb tested alone did not affect KC\u2010induced neutrophil migration after 2 or 4\u2003h. Moreover, anti\u2010E\u2010selectin did not have an additive inhibitory effect on KC\u2010induced neutrophil migration compared with P\u2010selectin blockade alone. This was found when neutrophil migration was measured at 2 and 4\u2003h after KC.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Despite a blood neutrophilia, neutrophil migration at 2 and 4\u2003h after KC was markedly smaller (by approximately 90%) in P\u2010selectin deficient mice compared with wild type animals. Responses at both time points were not decreased further in animals given E\u2010selectin mAb but were reduced to the PBS control level in the presence of anti\u2010L\u2010selectin.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p><jats:italic>In vitro<\/jats:italic> study of cultured murine endothelial cells demonstrated that KC can directly increase cell surface P\u2010selectin expression.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These data suggest that CXC chemokine\u2010induced neutrophil accumulation is dependent on both neutrophil L\u2010selectin and a rapid upregulation of endothelial P\u2010selectin but there is no evidence for E\u2010selectin induction.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2001) <jats:bold>133<\/jats:bold>, 550\u2013556; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0704118\">10.1038\/sj.bjp.0704118<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0704118","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T21:29:10Z","timestamp":1106947750000},"page":"550-556","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Dominant role of L\u2010 and P\u2010selectin in mediating CXC chemokine\u2010induced neutrophil migration <i>in vivo<\/i>"],"prefix":"10.1111","volume":"133","author":[{"given":"Jadwiga M","family":"Miotla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria C","family":"Ridger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul G","family":"Hellewell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000237207"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/33340"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830241215"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)43882-3"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.154.11.6048"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117856"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1993.1486"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117745"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117430"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/304030a0"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/15419069409014198"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.15.5.8918372"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1996.0658"},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"5297","DOI":"10.1182\/blood.V87.12.5297.bloodjournal87125297","article-title":"Selectins mediate eosinophil recruitment in vivo: a comparison with their role in neutrophil influx","volume":"87","author":"HENRIQUES M.G.M.O.","year":"1996","journal-title":"Blood"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1840701"},{"key":"e_1_2_7_17_1","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1182\/blood.V76.1.178.178","article-title":"Regulation and lectin activity of the human neutrophil peripheral lymph node homing receptor","volume":"76","author":"JUTILA M.A.","year":"1990","journal-title":"Blood"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.124.4.609"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.77.5.879"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2551036"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(94)90041-8"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.155.4.2158"},{"key":"e_1_2_7_23_1","doi-asserted-by":"crossref","first-page":"16283","DOI":"10.1016\/S0021-9258(18)41997-7","article-title":"Characterisation of two high affinity human interleukin\u20108 receptors","volume":"267","author":"LEE J.R.","year":"1992","journal-title":"J. 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