{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T13:50:31Z","timestamp":1782481831812,"version":"3.54.5"},"reference-count":52,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":2677,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2001,10]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Adenosine produced a biphasic lowering of the mean BP with a drastic bradycardic effect at the highest doses. The first phase hypotensive response was significantly reduced by the nitric oxide (NO) synthase inhibitor <jats:sc>L<\/jats:sc>\u2010NAME.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The A<jats:sub>2a<\/jats:sub>\/A<jats:sub>2b<\/jats:sub> agonist NECA produced hypotensive and bradycardic responses similar to those elicited by adenosine, which were not significantly modified by the A<jats:sub>2b<\/jats:sub> antagonist enprofylline.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The A<jats:sub>2a<\/jats:sub> agonist CGS 21680 did not significantly influence basal HR while induced a hypotensive response antagonized by the A<jats:sub>2a<\/jats:sub> selective antagonist ZM 241385, and reduced by both <jats:sc>L<\/jats:sc>\u2010NAME and the guanylate cyclase inhibitor methylene blue.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The A<jats:sub>1<\/jats:sub> agonist R\u2010PIA showed a dose\u2010dependent decrease in BP with a drastic decrease in HR at the highest doses. The A<jats:sub>1<\/jats:sub> selective antagonist DPCPX significantly reduced the bradycardic activity and also the hypotensive responses obtained with the lowest doses while it increased those obtained with the highest ones.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The A<jats:sub>1<\/jats:sub>\/A<jats:sub>3<\/jats:sub> agonist APNEA, in the presence of the xanthinic non\u2010selective antagonist 8\u2010pSPT, maintained a significant hypotensive, but not bradycardic, activity, not abolished by the histamine antagonist diphenhydramine.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The selective A<jats:sub>3<\/jats:sub> agonist IB\u2010MECA revealed a weak hypotensive and bradycardic effect, but only at the highest doses.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In conclusion, in the systemic cardiovascular response to adenosine two major components may be relevant: an A<jats:sub>2a<\/jats:sub>\u2010 and NO\u2010mediated hypotension, and a bradycardic effect with a consequent hypotension, <jats:italic>via<\/jats:italic> atypical A<jats:sub>1<\/jats:sub> receptors. Finally, an 8\u2010pSPT\u2010resistant hypotensive response not attributable to A<jats:sub>3<\/jats:sub> receptor\u2010stimulation or to release of histamine by mastocytes or other immune cells was observed.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2001) <jats:bold>134<\/jats:bold>, 745\u2013752; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0704301\">10.1038\/sj.bjp.0704301<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0704301","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T22:04:01Z","timestamp":1106949841000},"page":"745-752","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Adenosine\u2010mediated hypotension in <i>in vivo<\/i> guinea\u2010pig: receptors involved and role of NO"],"prefix":"10.1111","volume":"134","author":[{"given":"P","family":"Nieri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Martinotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Calderone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M C","family":"Breschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"H1672","article-title":"Role of nitric oxide in adenosine receptor\u2010mediated relaxation of porcine coronary artery","volume":"269","author":"ABEBE W.","year":"1995","journal-title":"Am. 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