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In the IgE\u2010mediated skin reaction, OJ\u2010R9188 at 3 and 10\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, i.v. significantly inhibited extravasation of neutrophils and eosinophils into the inflammatory sites and at 10\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, i.v. also inhibited infiltration caused by picryl chloride\u2010induced delayed\u2010type hypersensitivity in mice. These results suggest that OJ\u2010R9188 may be a useful selectin blocker, with activity against human and mouse E\u2010, P\u2010 and L\u2010selectins <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>, and that blocking selectin\u2010sLe<jats:sup>x<\/jats:sup> binding is a promising strategy for the treatment of allergic skin diseases.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2001) <jats:bold>134<\/jats:bold>, 1498\u20131504; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" 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