{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T15:41:25Z","timestamp":1782142885303,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":2616,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2001,12]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Melanotan\u2010II had been reported to cause penile erections in men with erectile dysfunction. In the present study, we investigated the mechanisms by which systemic administration of MT\u2010II increases intracavernosal pressure in anaesthetized rabbits.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>MT\u2010II (10\u2003\u03bc<jats:sc>M<\/jats:sc>) had no effect on electrical field stimulation\u2010evoked relaxations of rabbit corpus cavernosal strips <jats:italic>in vitro<\/jats:italic>.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Intravenous injection of MT\u2010II (66 and 133\u2003\u03bcg\u2003kg<jats:sup>\u22121<\/jats:sup> elicited dose\u2010related increases in cavernosal pressure. SHU 9119 (3\u2003\u03bcg\u2003kg<jats:sup>\u22121<\/jats:sup>, i.v.), a non\u2010selective antagonist of MC<jats:sub>3<\/jats:sub> and MC<jats:sub>4<\/jats:sub> receptors did not significantly affect either cavernosal pressure or systemic blood pressure but abolished the MT\u2010II\u2010induced increases in cavernosal pressure. SHU 9119 also inhibited the depressor response produced by MT\u2010II.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Intracavernosal injection 100\u2003\u03bcl of the cocktail containing phentolamine mesylate (1\u2003mg\u2003ml<jats:sup>\u22121<\/jats:sup>), papaverine (20\u2003mg\u2003ml<jats:sup>\u22121<\/jats:sup>) and PGE1 (20\u2003\u03bcg\u2003ml<jats:sup>\u22121<\/jats:sup>) increased the cavernosal pressure by about 4 fold.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The role of NO\u2010cyclic GMP dependent pathway to MT\u2010II\u2010induced increases in cavernosal pressure was investigated by bilateral transection of the pudendal nerves and by inhibition of NO synthase with <jats:sc>L<\/jats:sc>\u2010NAME (20\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, i.v. over 30\u2003min). Ablation of the pudendal nerves or pretreatment with <jats:sc>L<\/jats:sc>\u2010NAME abolished the MT\u2010II\u2010induced increases in intracavernosal pressure in anaesthetized rabbits.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The data suggest that activation of central melanocortin receptors by MT\u2010II increases cavernosal pressure by the neuronal release of NO.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2001) <jats:bold>134<\/jats:bold>, 1705\u20131710; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0704437\">10.1038\/sj.bjp.0704437<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0704437","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T21:39:21Z","timestamp":1106948361000},"page":"1705-1710","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Activation of central melanocortin receptors by MT\u2010II increases cavernosal pressure in rabbits by the neuronal release of NO"],"prefix":"10.1111","volume":"134","author":[{"given":"Rao","family":"Vemulapalli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stan","family":"Kurowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Salisbury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Parker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(97)00078-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(99)00465-3"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm00132a010"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00191a044"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)69009-X"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1995.75.1.191"},{"key":"e_1_2_6_8_1","doi-asserted-by":"crossref","unstructured":"ARGIOLAS A.&MELIS M.R.(1995).Neuromodulation of penile erection. 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