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PCP (0.1\u2003\u2013\u20033\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>s.c.) caused a marked dose\u2010dependent increase in EEG power in the frontal cortex at 1\u2003\u2013\u20033\u2003Hz with decreases in power at higher frequencies (9\u2003\u2013\u200330\u2003Hz). At high doses (3\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>s.c.) the entire spectrum shifted to more positive values, indicating an increase in cortical synchronization. MK 801 (0.05\u2003\u2013\u20030.1\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>i.p.) caused similar effects but with lesser changes in power.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>In contrast, the non\u2010competitive AMPA antagonists GYKI 52466 and GYKI 53655 increased EEG power over the whole power spectrum (1\u2003\u2013\u200310\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>i.p.) The atypical antipsychotic clozapine (0.2\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>s.c.) synchronized the EEG (peak 8\u2003Hz). The 5\u2010HT<jats:sub>2A<\/jats:sub>\u2010antagonist, M100907, specifically increased EEG power at 2\u2003\u2013\u20033\u2003Hz at low doses (10 and 50\u2003\u03bcg\u2003kg<jats:sup>\u00f71<\/jats:sup>s.c.), whereas at higher doses (0.1\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>s.c.) the profile resembled that of clozapine.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>Clozapine (0.2\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>s.c.), GYKI 53655 (5\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>i.p.), prazosin (0.05 and 0.1\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>i.p.), and M100907 (0.01 and 0.05\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>s.c.) antagonized the decrease in power between 5 and 30\u2003Hz caused by PCP (1\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>s.c.), but not the increase in power at 1\u2003\u2013\u20033\u2003Hz in prefrontal cortex.<\/jats:p><\/jats:list-item><\/jats:list><\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic>(2002)<jats:bold>135<\/jats:bold>, 65\u201378; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0704451\">10.1038\/sj.bjp.0704451<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0704451","type":"journal-article","created":{"date-parts":[[2006,6,7]],"date-time":"2006-06-07T19:20:37Z","timestamp":1149708037000},"page":"65-78","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Effects of phencyclidine (PCP) and MK 801 on the EEGq in the prefrontal cortex of conscious rats; antagonism by clozapine, and antagonists of AMPA\u2010, \u03b1<sub>1<\/sub>\u2010 and 5\u2010HT<sub>2A<\/sub>\u2010receptors"],"prefix":"10.1111","volume":"135","author":[{"given":"Claude","family":"Sebban","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Tesolin\u2010Decros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Ciprian\u2010Ollivier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Perret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Spedding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-979354"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1995.tb15106.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(97)00051-8"},{"key":"e_1_2_7_5_1","first-page":"1366","article-title":"Serotonin2A receptors selectively enhance asynchronous excitatory transmission in layer V cortical pyramidal cells","volume":"24","author":"AGHAJANIAN G.K.","year":"1998","journal-title":"Soc. 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