{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:15:52Z","timestamp":1761707752576},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,2,2]],"date-time":"2009-02-02T00:00:00Z","timestamp":1233532800000},"content-version":"vor","delay-in-days":2558,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2002,2]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>The maintenance of renal function in decompensated cirrhosis is highly dependent on prostaglandins (PGs). Since PG synthesis is mediated by cyclooxygenase\u20101 and \u22122 (COX\u20101 and COX\u20102), the present study was designed to examine which COX isoform is involved in this phenomenon.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Renal COX\u20101 and COX\u20102 protein expression and distribution were analysed by Western blot and immunohistochemistry in nine rats with carbon tetrachloride\u2010induced cirrhosis and ascites and 10 control animals. The effects of placebo and selective COX\u20101 (SC\u2010560) and COX\u20102 (celecoxib) inhibitors on urine flow (V), urinary excretion of sodium (U<jats:sub>Na<\/jats:sub>V) and PGE<jats:sub>2<\/jats:sub> (U<jats:sub>PGE2<\/jats:sub>V), glomerular filtration rate (GFR), renal plasma flow (RPF), the diuretic and natriuretic responses to furosemide and renal water metabolism were assessed in 88 rats with cirrhosis and ascites.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>COX\u20101 protein levels were found to be unchanged in kidneys from cirrhotic rats. In contrast, these animals showed enhanced renal COX\u20102 protein expression which was focally increased in the corticomedullary region. Although U<jats:sub>PGE2<\/jats:sub>V was equally reduced by SC\u2010560 and celecoxib, only SC\u2010560 produced a significant decrease in U<jats:sub>Na<\/jats:sub>V, GFR and RPF and a pronounced impairment in the diuretic and natriuretic responses to furosemide in rats with cirrhosis and ascites. Neither SC\u2010560 nor celecoxib affected renal water metabolism in cirrhotic rats.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These results indicate that despite abundant renal COX\u20102 protein expression, the maintenance of renal function in cirrhotic rats is mainly dependent on COX\u20101\u2010derived prostaglandins.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2002) <jats:bold>135<\/jats:bold>, 891\u2013900; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0704528\">10.1038\/sj.bjp.0704528<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0704528","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T21:43:12Z","timestamp":1106948592000},"page":"891-900","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Cyclooxygenase\u20101 derived prostaglandins are involved in the maintenance of renal function in rats with cirrhosis and ascites"],"prefix":"10.1111","volume":"135","author":[{"given":"Marta","family":"L\u00f3pez\u2010Parra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Cl\u00e0ria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Planagum\u00e0","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Titos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime L","family":"Masferrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B Mark","family":"Woerner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alane T","family":"Koki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wladimiro","family":"Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosario","family":"Altuna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente","family":"Arroyo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisca","family":"Rivera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Rod\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1983.tb00100.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(86)90912-5"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200011233432103"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70020-X"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(79)90268-3"},{"key":"e_1_2_7_7_1","first-page":"735","article-title":"Effects of specific inhibition on cyclooxygenase\u20102 on sodium balance, hemodynamics and vasoactive eicosanoids","volume":"289","author":"CATELLA\u2010LAWSON F.","year":"1999","journal-title":"J. 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