{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T02:40:56Z","timestamp":1697510456496},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,2,2]],"date-time":"2009-02-02T00:00:00Z","timestamp":1233532800000},"content-version":"vor","delay-in-days":2558,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2002,2]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>This study examined the role of endothelin ET<jats:sub>A<\/jats:sub> and ET<jats:sub>B<\/jats:sub> receptors on haemodynamic compensation following haemorrhage (\u221217.5\u2003ml\u2003kg<jats:sup>\u22121<\/jats:sup>) in thiobutabarbitone\u2010anaesthetized rats. Rats were divided into four groups (<jats:italic>n<\/jats:italic>=6 each): time\u2010control, haemorrhage\u2010control, haemorrhage after treatment with FR 139317 (ET<jats:sub>A<\/jats:sub>\u2010receptor antagonist), and haemorrhage after treatment with BQ\u2010788 (ET<jats:sub>B<\/jats:sub>\u2010receptor antagonist).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In the time\u2010control rats, there were no significant changes in any haemodynamics for the duration of the experiments. Relative to the time\u2010control rats, rats given haemorrhage had reduced mean arterial pressure (MAP), cardiac output (CO) and mean circulatory filling pressure (MCFP), but increased systemic vascular resistance (R<jats:sub>SV<\/jats:sub>). Venous resistance (R<jats:sub>V<\/jats:sub>) was slightly (but insignificantly) reduced by haemorrhage. MAP, however, gradually returned towards baseline (\u221217\u00b14 and \u22123\u00b12\u2003mmHg at 10 and 60\u2003min after haemorrhage, respectively) as a result of a further increase in R<jats:sub>SV<\/jats:sub>.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Pre\u2010treatment with FR 139317 (i.v. 1\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, followed by 1\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>\u2003h<jats:sup>\u22121<\/jats:sup>) accentuated haemorrhage\u2010induced hypotension through abolition of the increase in R<jats:sub>SV<\/jats:sub>. FR 139317 did not modify haemorrhage\u2010induced changes in CO, MCFP and R<jats:sub>V<\/jats:sub>.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Pre\u2010treatment of BQ\u2010788 (3\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>) did not affect MAP or MCFP following haemorrhage; however, CO was lower, and R<jats:sub>SV<\/jats:sub> as well as R<jats:sub>V<\/jats:sub> were higher relative to the readings in the haemorrhaged\u2010control rats.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These results show that following compensated haemorrhage, ET maintains arterial resistance and blood pressure <jats:italic>via<\/jats:italic> the activation of ET<jats:sub>A<\/jats:sub> but not ET<jats:sub>B<\/jats:sub> receptors.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2002) <jats:bold>135<\/jats:bold>, 876\u2013882; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0704530\">10.1038\/sj.bjp.0704530<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0704530","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T21:43:12Z","timestamp":1106948592000},"page":"876-882","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Role of endothelin ET<sub>A<\/sub>\u2010 and ET<sub>B<\/sub>\u2010receptors in haemodynamic compensation following haemorrhage in anaesthetized rats"],"prefix":"10.1111","volume":"135","author":[{"given":"Beatriz","family":"Palacios","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su Lin","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine C Y","family":"Pang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1995.tb15099.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-199312000-00003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1152\/physrev.1967.47.2.214","article-title":"Role of sympathetic nervous system in hemorrhage","volume":"47","author":"CHIEN S.","year":"1967","journal-title":"Physiol. 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