{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T21:57:30Z","timestamp":1775080650317,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,2,2]],"date-time":"2009-02-02T00:00:00Z","timestamp":1233532800000},"content-version":"vor","delay-in-days":2558,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2002,2]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Orphanin FQ (OFQ), an endogenous peptide for ORL1 receptors, has been identified. Although the actions of OFQ have much in common with those of opioid peptides at the cellular level, behavioral studies in rodents seem conflicting.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The aim of this study was to investigate the potential pronociceptive or antinociceptive function of peripheral ORL1 receptors in primates. Experiments were conducted to verify whether local administration of OFQ can attenuate capsaicin\u2010induced nociception and whether peripheral ORL1 receptors selectively mediate the local action of OFQ in monkeys.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Capsaicin (100\u2003\u03bcg) was administered subcutaneously in the tail to locally evoke a nociceptive response (thermal allodynia\/hyperalgesia), which was manifested as a reduced tail\u2010withdrawal latency in normally innocuous 46\u00b0C warm water.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Co\u2010administration of OFQ (1\u2003\u2013\u200330\u2003\u03bcg) with capsaicin in the tail dose\u2010dependently inhibited thermal nociception. However, a locally effective dose of OFQ (30\u2003\u03bcg), when applied in the back, did not inhibit capsaicin\u2010induced nociception.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>OFQ\u2010induced local antinociception was antagonized by a small dose (10\u2003\u03bcg) of J\u2010113397, a selective ORL1 receptor antagonist, in the tail. Similarly, s.c. administration of 10\u2003\u03bcg of J\u2010113397 in the back did not antagonize local antinociception of OFQ.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In addition, s.c. administration of either OFQ or J\u2010113397 in the tail alone did not change its thermal nociceptive threshold. Local administration of opioid receptor antagonists selective for mu, kappa, and delta opioid receptors did not antagonize OFQ\u2010induced local antinociception. Local administration of J\u2010113397 also did not interfere with the local actions of mu, kappa, and delta opioid agonists in the tail.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These results provide the first functional evidence that activation of peripheral ORL1 receptors produces thermal antinociception in primates and this action is independent of antinociception produced at classical opioid receptors.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2002) <jats:bold>135<\/jats:bold>, 943\u2013950; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0704535\">10.1038\/sj.bjp.0704535<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0704535","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T21:43:12Z","timestamp":1106948592000},"page":"943-950","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Orphanin FQ inhibits capsaicin\u2010induced thermal nociception in monkeys by activation of peripheral ORL1 receptors"],"prefix":"10.1111","volume":"135","author":[{"given":"M C H","family":"Ko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N N","family":"Naughton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J R","family":"Traynor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M S","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J H","family":"Woods","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K C","family":"Rice","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A T","family":"McKnight","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)90456-1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-01-00165.1995"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00175710"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(95)00134-7"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703219"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5464.306"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/39807"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15387.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(97)01204-6"},{"key":"e_1_2_7_11_1","first-page":"812","article-title":"Pharmacological characterization of the novel nonpeptide orphanin FQ\/nociceptin receptor agonist Ro 64\u20106198: rapid and reversible desensitization of the ORL1 receptor in vitro and lack of tolerance in vivo","volume":"298","author":"DAUTZENBERG F.M.","year":"2001","journal-title":"J. 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