{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:39:05Z","timestamp":1761154745732},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,2,2]],"date-time":"2009-02-02T00:00:00Z","timestamp":1233532800000},"content-version":"vor","delay-in-days":2530,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2002,3]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>The activation of eosinophils <jats:italic>via<\/jats:italic> G\u2010protein\u2010coupled seven transmembran receptors play a necessary role in the recruitment of these cells into tissue. The present study investigates a role for PAF in driving eotaxin production and eosinophil recruitment in an allergic pleurisy model in mice.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The intrapleural injection of increasing doses of PAF (10<jats:sup>\u221211<\/jats:sup> to 10<jats:sup>\u22129<\/jats:sup> moles per cavity) induced a dose\u2010 and PAF receptor\u2010dependent recruitment of eosinophils 48\u2003h after stimulation.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Intrapleural injection of PAF induced the rapid (within 1\u2003h) release of eotaxin into the pleural cavity of mice and an anti\u2010eotaxin antibody effectively inhibited PAF\u2010induced recruitment of eosinophils.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Eosinophil recruitment in the allergic pleurisy was markedly inhibited by the PAF receptor antagonist UK\u201074,505 (modipafant, 1\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>). Moreover, recruitment of eosinophils in sensitized and challenged PAF receptor\u2010deficient animals was lower than that observed in wild\u2010type animals.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Blockade of PAF receptors with UK\u201074,505 suppressed by 85% the release of eotaxin in the allergic pleurisy.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Finally, the injection of a sub\u2010threshold dose of PAF and eotaxin cooperated to induce eosinophil recruitment <jats:italic>in vivo<\/jats:italic>.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In conclusion, the production of PAF in an allergic reaction could function in multiple ways to facilitate the recruitment of eosinophils \u2003\u2013\u2003 by facilitating eotaxin release and by cooperating with eotaxin to induce greater recruitment of eosinophils.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2002) <jats:bold>135<\/jats:bold>, 1213\u20131218; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0704570\">10.1038\/sj.bjp.0704570<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0704570","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T21:46:17Z","timestamp":1106948777000},"page":"1213-1218","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Platelet\u2010activating factor drives eotaxin production in an allergic pleurisy in mice"],"prefix":"10.1111","volume":"135","author":[{"given":"Andr\u00e9","family":"Klein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Pinho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Let\u00edcia","family":"Alessandrini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro M","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,2]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"221","article-title":"UK\u201074505, a novel and selective PAF antagonist, exhibits potent and long lasting activity in vivo","volume":"34","author":"ALABASTER V.A.","year":"1991","journal-title":"Agents Actions Suppl."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(96)00357-3"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(01)01141-4"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.4049\/jimmunol.162.5.2982","article-title":"Endogenous platelet\u2010activating factor is critically involved in effector functions of eosinophils stimulated with IL\u20105 or IgG","volume":"162","author":"BARTEMES K.R.","year":"1999","journal-title":"J. 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