{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T07:06:13Z","timestamp":1769151973801,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,2,2]],"date-time":"2009-02-02T00:00:00Z","timestamp":1233532800000},"content-version":"vor","delay-in-days":2499,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2002,4]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item>\n<jats:p>Heat stress (HS) is known to protect the myocardium against ischaemic damage. It has been reported that reactive oxygen species (ROS) are abundantly produced during this stress. Since mechanisms triggering the HS\u2010induced cardioprotection remain unknown, we investigated the role of ROS in the genesis of this protective phenomenon.<\/jats:p>\n<\/jats:list-item>\n<jats:list-item>\n<jats:p>Rats were divided into four groups (<jats:italic>n<\/jats:italic>=8 in each group), subjected to either hyperthermia (42\u00b0C internal temperature for 15\u2003min) or sham anaesthesia and treated or not with <jats:italic>N<\/jats:italic>\u20102\u2010mercaptopropionyl glycine (MPG), a synthetic antioxidant, 10\u2003min before HS. Twenty\u2010four hours later, their hearts were isolated, retrogradely perfused, and subjected to a 30\u2010min occlusion of the left coronary artery followed by 120\u2003min of reperfusion. Myocardial Hsp 27 and 70 expression was assessed by Western blot analysis (<jats:italic>n<\/jats:italic>=4). Cardiac activities of antioxidant enzymes (superoxide dismutase and glutathione peroxidase) were also examined (<jats:italic>n<\/jats:italic>=4).<\/jats:p>\n<\/jats:list-item>\n<jats:list-item>\n<jats:p>Infarct\u2010to\u2010risk zone ratio was significantly reduced in HS (17\u00b11.3%) compared to Sham (34.3\u00b11.7%) hearts. This effect was abolished by MPG pretreatment (40.6\u00b11.9% in HS+MPG <jats:italic>vs<\/jats:italic> 39.8\u00b12.5% in Sham+MPG hearts). This cardioprotection was associated with an enhanced Hsp 27 and 70 expression, which was not modified by MPG pretreatment. Antioxidant enzyme activities was not modified by heat stress or MPG pretreatment.<\/jats:p>\n<\/jats:list-item>\n<jats:list-item>\n<jats:p>Free radical production following hyperthermia appears to play a role in the heat stress induced cardioprotection, independently of Hsp levels. Antioxidant enzyme activities do not seem to be implicated in this cardioprotective mechanism.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2002) <jats:bold>135<\/jats:bold>, 1776\u20131782; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0704619\">10.1038\/sj.bjp.0704619<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0704619","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T21:50:25Z","timestamp":1106949025000},"page":"1776-1782","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Free\u2010radical production triggered by hyperthermia contributes to heat stress\u2010induced cardioprotection in isolated rat hearts"],"prefix":"10.1111","volume":"135","author":[{"given":"Claire","family":"Arnaud","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Joyeux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Garrel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane","family":"Godin\u2010Ribuot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Demenge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Ribuot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703942"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.87.11.972"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.65.3.607"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.63.3.543"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.85.2.769"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(98)00779-0"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.1.355"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1997.0556"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702137"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.1999.tb00314.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.88.3.1264"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117059"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1974.tb03714.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.12.4343"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.9.381"},{"key":"e_1_2_6_17_1","first-page":"109","article-title":"Nitric oxide: physiology, pathophysiology, and pharmacology","volume":"43","author":"MONCADA S.","year":"1991","journal-title":"Pharmacol. 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