{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T12:50:36Z","timestamp":1789908636902,"version":"4.0.1"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,2,2]],"date-time":"2009-02-02T00:00:00Z","timestamp":1233532800000},"content-version":"vor","delay-in-days":2499,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2002,4]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item>\n<jats:p>The role of cannabinoid (CB) receptors in the regulation of gastric acid secretion was investigated in the rat by means of functional experiments and by immunohistochemistry.<\/jats:p>\n<\/jats:list-item>\n<jats:list-item>\n<jats:p>In anaesthetized rats with lumen\u2010perfused stomach, the non selective CB\u2010receptor agonist WIN 55,212\u20102 (0.30\u2003\u2013\u20034.00\u2003\u03bcmol\u2003kg<jats:sup>\u22121<\/jats:sup>, i.v.) and the selective CB<jats:sub>1<\/jats:sub>\u2010receptor agonist HU\u2010210 (0.03\u2003\u2013\u20031.50\u2003\u03bcmol\u2003kg<jats:sup>\u22121<\/jats:sup>, i.v.), dose\u2010dependently decreased the acid secretion induced by both pentagastrin (30\u2003nmol\u2003kg<jats:sup>\u22121<\/jats:sup>\u2003h<jats:sup>\u22121<\/jats:sup>) and 2\u2010deoxy\u2010D\u2010glucose (1.25\u2003mmol\u2003kg<jats:sup>\u22121<\/jats:sup>, i.v.). By contrast, neither WIN 55,212\u20102 (1\u2003\u2013\u20034\u2003\u03bcmol\u2003kg<jats:sup>\u22121<\/jats:sup>, i.v.) nor HU\u2010210 (0.03\u2003\u2013\u20031.50\u2003\u03bcmol\u2003kg<jats:sup>\u22121<\/jats:sup>, i.v.) did modify histamine\u2010induced acid secretion (20\u2003\u03bcmol\u2003kg<jats:sup>\u22121<\/jats:sup>\u2003h<jats:sup>\u22121<\/jats:sup>). The selective CB<jats:sub>2<\/jats:sub>\u2010receptor agonist JWH\u2010015 (3\u2003\u2013\u200310\u2003\u03bcmol\u2003kg<jats:sup>\u22121<\/jats:sup>, i.v.) was ineffective.<\/jats:p>\n<\/jats:list-item>\n<jats:list-item>\n<jats:p>The gastric antisecretory effects of WIN 55,212\u20102 and HU\u2010210 on pentagastrin\u2010induced acid secretion were prevented by the selective CB<jats:sub>1<\/jats:sub>\u2010receptor antagonist SR141716A (0.65\u2003\u03bcmol\u2003kg<jats:sup>\u22121<\/jats:sup>, i.v.) and unaffected by the selective CB<jats:sub>2<\/jats:sub>\u2010receptor antagonist SR144528 (0.65\u2003\u2013\u20032\u2003\u03bcmol\u2003kg<jats:sup>\u22121<\/jats:sup>, i.v.).<\/jats:p>\n<\/jats:list-item>\n<jats:list-item>\n<jats:p>Bilateral cervical vagotomy and ganglionic blockade with hexamethonium (10\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, i.v., followed by continuous infusion of 10\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>\u2003h<jats:sup>\u22121<\/jats:sup>) significantly reduced, but not abolished, the maximal inhibitory effect of HU\u2010210 (0.3\u2003\u03bcmol\u2003kg<jats:sup>\u22121<\/jats:sup>, i.v.) on pentagastrin\u2010induced acid secretion; by contrast, pretreatment with atropine (1\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, i.v.) did not modify the antisecretory effect of HU\u2010210.<\/jats:p>\n<\/jats:list-item>\n<jats:list-item>\n<jats:p>Immunoreactivity to the CB<jats:sub>1<\/jats:sub> receptor was co\u2010localized with that of the cholinergic marker choline acetyltransferase in neural elements innervating smooth muscle, mucosa and submucosal blood vessels of rat stomach fundus, corpus and antrum. In contrast, CB<jats:sub>2<\/jats:sub> receptor\u2010like immunoreactivity was not observed.<\/jats:p>\n<\/jats:list-item>\n<jats:list-item>\n<jats:p>These results indicate that gastric antisecretory effects of cannabinoids in the rat are mediated by suppression of vagal drive to the stomach through activation of CB<jats:sub>1<\/jats:sub> receptors, located on pre\u2010 and postganglionic cholinergic pathways. However, the ineffectiveness of atropine in reducing the effect of HU\u2010210 suggests that the release of non cholinergic excitatory neurotransmitters may be regulated by CB<jats:sub>1<\/jats:sub> receptors.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2002) <jats:bold>135<\/jats:bold>, 1598\u20131606; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0704625\">10.1038\/sj.bjp.0704625<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0704625","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T21:50:25Z","timestamp":1106949025000},"page":"1598-1606","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Gastric antisecretory role and immunohistochemical localization of cannabinoid receptors in the rat stomach"],"prefix":"10.1111","volume":"135","author":[{"given":"Maristella","family":"Adami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Frati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Bertini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Kulkarni\u2010Narla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe de","family":"Caro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Coruzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Soldani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,2,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1211\/146080800128735953"},{"key":"e_1_2_6_3_1","first-page":"244P","article-title":"Investigation of CB1 cannabinoid receptors mediating antisecretory effects in rat stomach","volume":"133","author":"ADAMI M.","year":"2001","journal-title":"Br. 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