{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:20:25Z","timestamp":1790824825284,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,2,2]],"date-time":"2009-02-02T00:00:00Z","timestamp":1233532800000},"content-version":"vor","delay-in-days":2469,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>This study examined whether NO is involved in the <jats:italic>in\u2010vivo<\/jats:italic> coronary vasodilator effects of amlodipine (a calcium channel blocker) and whether heart failure (HF) alters the coronary responses to amlodipine.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Nine conscious dogs were chronically instrumented to measure circumflex coronary blood flow (CBF) and coronary diameter (CD). Drugs were administered directly into the circumflex artery through an indwelling catheter to avoid systemic changes. HF was induced by right ventricular pacing (240 b.p.m., 3 weeks).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Compared with control (C), in HF, coronary responses to acetylcholine (1\u201310\u2003ng\u2003kg<jats:sup>\u22121<\/jats:sup>) were reduced while responses to nitroglycerin (0.1\u20130.5\u2003\u03bcg\u2003kg<jats:sup>\u22121<\/jats:sup>) were unchanged. In C, amlodipine (30\u2013150\u2003\u03bcg\u2003kg<jats:sup>\u22121<\/jats:sup>), increased dose\u2010dependently CBF and CD. After LNA (a NO synthase inhibitor, 2\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>), amlodipine produced less increases in CBF and CD (+121\u00b126\u2003ml\u2003min<jats:sup>\u22121<\/jats:sup> and +76\u00b135\u2003\u03bcm versus +196\u00b140\u2003ml\u2003min<jats:sup>\u22121<\/jats:sup> and +153\u00b139\u2003\u03bcm respectively for 150\u2003\u03bcg\u2003kg<jats:sup>\u22121<\/jats:sup> amlodipine alone, both <jats:italic>P<\/jats:italic>&lt;0.05). In HF, the coronary responses to amlodipine were reduced (150\u2003\u03bcg\u2003kg<jats:sup>\u22121<\/jats:sup> of amlodipine increased CBF and CD +121\u00b123\u2003ml\u2003min<jats:sup>\u22121<\/jats:sup> and +77\u00b121\u2003\u03bcm respectively, both <jats:italic>P<\/jats:italic>&lt;0.05). After LNA, the CBF responses to amlodipine tended to be reduced (+94\u00b119\u2003ml\u2003min<jats:sup>\u22121<\/jats:sup> at 150\u2003\u03bcg\u2003kg<jats:sup>\u22121<\/jats:sup>) but CD responses were significantly reduced (+41\u00b116\u2003\u03bcm, <jats:italic>P<\/jats:italic>&lt;0.05). The supplementation with <jats:sc>L<\/jats:sc>\u2010arginine did not enhance the coronary responses to amlodipine.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These results indicate that, in conscious dogs, NO participates in the coronary responses to amlodipine and in HF, the coronary responses to amlodipine are reduced, which is related to a reduced NO production.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2002) <jats:bold>136<\/jats:bold>, 264\u2013270; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0704701\">10.1038\/sj.bjp.0704701<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0704701","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T21:54:48Z","timestamp":1106949288000},"page":"264-270","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Reduced coronary vasodilator responses to amlodipine in pacing\u2010induced heart failure in conscious dogs: role of nitric oxide"],"prefix":"10.1111","volume":"136","author":[{"given":"St\u00e9phane","family":"Champagne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Hittinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"H\u00e9loire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Suto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucien","family":"Sambin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Crozatier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Bo","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,2,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.74.5.1075"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.1.375"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1995.tb13254.x"},{"issue":"3","key":"e_1_2_6_5_1","first-page":"98","article-title":"Two different mechanisms of anti\u2010anginal drugs on epicardial coronary arteries in vivo: indirect, flow\u2010dependent, endothelium mediated dilation and direct smooth mucle relaxation","volume":"72","author":"HOLTZ J.","year":"1983","journal-title":"Z. Kardiol."},{"key":"e_1_2_6_6_1","first-page":"H1266","article-title":"Regional myocardial effects of intracoronary bradykinin in conscious dogs","volume":"272","author":"HOUEL R.","year":"1997","journal-title":"Am. J. Physiol."},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.16.2113"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.88.1.55"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.3.311"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00556-7"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.84.4.1589"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1006\/niox.2000.0326"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.83.10.969"},{"key":"e_1_2_6_14_1","first-page":"H80","article-title":"Alterations of endothelium\u2010dependent and independent regulation of coronary blood flow during heart failure","volume":"282","author":"SAITO T.","year":"2002","journal-title":"Am. J. Physiol."},{"key":"e_1_2_6_15_1","first-page":"H1903","article-title":"Alterations in myocardial contractility in conscious dogs with dilated cardiomyopathy","volume":"260","author":"SHANNON R.P.","year":"1991","journal-title":"Am. J. Physiol."},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00465-3"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.78.1.58"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.85.2.717"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.25.2911"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.15.1848"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1994.tb17002.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115969"},{"key":"e_1_2_6_23_1","first-page":"H670","article-title":"Defective endothelium\u2010mediated control of coronary circulation in conscious dogs after heart failure","volume":"266","author":"WANG J.","year":"1994","journal-title":"Am. J. Physiol."},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91403-6"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199602000-00010"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/28.2.209"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.6.576"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)00362-8"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.10.2655"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.bjp.0704701","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.bjp.0704701","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/sj.bjp.0704701","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T10:52:24Z","timestamp":1697539944000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1038\/sj.bjp.0704701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,5]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,5]]}},"alternative-id":["10.1038\/sj.bjp.0704701"],"URL":"https:\/\/doi.org\/10.1038\/sj.bjp.0704701","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,5]]},"assertion":[{"value":"2009-02-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}