{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:51:15Z","timestamp":1761580275394},"reference-count":58,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,2,2]],"date-time":"2009-02-02T00:00:00Z","timestamp":1233532800000},"content-version":"vor","delay-in-days":2469,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Corticotropin\u2010releasing factor (CRF) acts in the brain to inhibit thyrotropin\u2010releasing hormone (TRH) analogue, RX\u201077368\u2010induced vagal stimulation of gastric motility. We investigated CRF receptor\u2010mediated actions of rat urocortin (rUcn) injected intracisternally (ic) on gastric motor function.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Urethane\u2010anaesthetized rats with strain gauges on the gastric corpus were injected i.c. with rUcn and 20\u2003min later, with i.c. RX\u201077368. CRF antagonists were injected i.c. 10\u2003min before rUcn.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>RX\u201077368 (1.5, 3, 10, 30 and 100\u2003ng, i.c.) dose\u2010dependently increased corpus contractions, expressed as total area under the curve (AUC, mV\u2003min<jats:sup>\u22121<\/jats:sup>) to 2.6\u00b12.5, 6.1\u00b15.9, 9.8\u00b12.6, 69.7\u00b121.7 and 74.9\u00b128.7 respectively <jats:italic>vs<\/jats:italic> 0.2\u00b10.1 after i.c. saline. Ucn (1, 3 or 10\u2003\u03bcg) inhibited RX\u201077368 (30\u2003ng)\u2010induced increase in total AUC by 28, 62 and 93% respectively <jats:italic>vs<\/jats:italic> i.c. saline+RX\u201077368.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The CRF<jats:sub>1<\/jats:sub>\/CRF<jats:sub>2<\/jats:sub> antagonist, astressin\u2010B (60\u2003\u03bcg, i.c.) completely blocked i.c. rUcn (3\u2003\u03bcg, i.c.)\u2010induced inhibition of gastric motility stimulated by RX\u201077368 (30\u2003ng).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The selective CRF<jats:sub>2<\/jats:sub> antagonist, astressin<jats:sub>2<\/jats:sub>\u2010B (30, 60 or 100\u2003\u03bcg, i.c.) dose\u2010dependently prevented i.c. rUCn action while the CRF<jats:sub>1<\/jats:sub> antagonist, NBI\u201027914 did not.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In conscious rats, rUcn (0.6 or 1\u2003\u03bcg, i.c.) inhibited gastric emptying of an ingested chow meal by 61 and 92% respectively. rUcn action was antagonized by astressin<jats:sub>2<\/jats:sub>\u2010B.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These data show that i.c. rUcn acts through CRF<jats:sub>2<\/jats:sub> receptors to inhibit central vagal gastric contractile response and postoprandial emptying.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2002) <jats:bold>136<\/jats:bold>, 237\u2013247; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0704713\">10.1038\/sj.bjp.0704713<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0704713","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T21:54:48Z","timestamp":1106949288000},"page":"237-247","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Intracisternal urocortin inhibits vagally stimulated gastric motility in rats: role of CRF<sub>2<\/sub>"],"prefix":"10.1111","volume":"136","author":[{"given":"C \u2010Y","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Million","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D W","family":"Adelson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Rivier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Tach\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70491-9"},{"key":"e_1_2_7_3_1","first-page":"R200","article-title":"Topography of efferent vagal innervation of the gastrointestinal tract","volume":"260","author":"BERTHOUD H.R.","year":"1991","journal-title":"Am. 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