{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:51:46Z","timestamp":1787766706265,"version":"build-2784847793"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,2,2]],"date-time":"2009-02-02T00:00:00Z","timestamp":1233532800000},"content-version":"vor","delay-in-days":2438,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>The effects of the nitric oxide (NO) donors S\u2010nitroso\u2010N\u2010acetylpenicillamine (SNAP), sodium(<jats:italic>Z<\/jats:italic>)\u20101\u2010(<jats:italic>N,N<\/jats:italic>\u2010diethylamino)diazen\u20101\u2010ium\u20101,2\u2010diolate (DEA\u2010NONOate), and (<jats:italic>Z<\/jats:italic>)\u20101\u2010[<jats:italic>N<\/jats:italic>\u2010(2\u2010Aminoethyl)\u2010<jats:italic>N<\/jats:italic>\u2010(2\u2010ammonioethyl)amino]diazen\u20101\u2010ium\u20101,2\u2010diolate (DETA\u2010NONOate) on force of contraction (F<jats:sub>c<\/jats:sub>) were studied in atrial and ventricular muscle strips obtained from wild\u2010type (WT) and myoglobin\u2010deficient (myo<jats:sup>\u2212\/\u2212<\/jats:sup>) mice.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>SNAP slightly reduced F<jats:sub>c<\/jats:sub> in preparations from WT mice at concentrations above 100\u2003\u03bc<jats:sc>M<\/jats:sc>; this effect was more pronounced in myo<jats:sup>\u2212\/\u2212<\/jats:sup> mice.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>DEA\u2010NONOate reduced F<jats:sub>c<\/jats:sub> in preparations from myo<jats:sup>\u2212\/\u2212<\/jats:sup> mice to a larger extent than those from WT mice.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>DETA\u2010NONOate reduced F<jats:sub>c<\/jats:sub> in preparations from myo<jats:sup>\u2212\/\u2212<\/jats:sup> but not from WT mice.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Pre\u2010incubation with an inhibitor of the soluble guanylyl cyclase (1<jats:italic>H<\/jats:italic>\u2010[1,2,4]oxadiazolo[4,3\u2010<jats:italic>a<\/jats:italic>]quinoxalin\u20101\u2010one; 100\u2003\u03bc<jats:sc>M<\/jats:sc>) prevented the effects of SNAP, DEA\u2010NONOate and DETA\u2010NONOate on F<jats:sub>c<\/jats:sub> in myo<jats:sup>\u2212\/\u2212<\/jats:sup> mice.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>It is suggested that, in physiological conditions, myoglobin acts as intracellular scavenger preventing NO from reaching its intracellular receptors in cardiomyocytes, whereas, in myoglobin\u2010deficient conditions, NO is able to reduce contractility <jats:italic>via<\/jats:italic> activation of the soluble guanylyl cyclase\/cyclic GMP pathway.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2002) <jats:bold>136<\/jats:bold>, 415\u2013420; 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