{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T14:10:01Z","timestamp":1697551801910},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,2,2]],"date-time":"2009-02-02T00:00:00Z","timestamp":1233532800000},"content-version":"vor","delay-in-days":2408,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2002,7]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>The antithrombotic effect of the glycoprotein IIb\/IIIa receptor antagonist, CRL42796, was examined in canine models of carotid and coronary artery thrombosis.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In the carotid artery thrombosis model, occlusion occurred in all control vessels (time to thrombosis 47.6\u00b18.9 min). After treatment with low dose CRL42796 (15 \u03bcg kg<jats:sup>\u22121<\/jats:sup> loading dose +0.31 \u03bcg kg<jats:sup>\u22121<\/jats:sup> min<jats:sup>\u22121<\/jats:sup> i.v.), two of five vessels occluded. Time to thrombosis increased significantly to 155.2\u00b123.1 min. When the drug infusion was increased (0.69 \u03bcg kg<jats:sup>\u22121<\/jats:sup> min<jats:sup>\u22121<\/jats:sup>), each of five vessels remained patent.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p><jats:italic>Ex vivo<\/jats:italic> platelet aggregation in response to arachidonic acid (AA) and ADP was examined in platelet rich plasma (PRP) prepared from citrate or heparin anticoagulated blood. CRL42796 reduced platelet reactivity at low and high doses in PRP from citrate anticoagulated blood. However, in PRP from heparin anticoagulated blood, only the higher infusion dose produced a significant reduction in <jats:italic>ex vivo<\/jats:italic> platelet responses.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>A combination of oral aspirin (4.6 mg kg<jats:sup>\u22121<\/jats:sup> \u221241, \u221217 h) and the low infusion dose of CRL42796 did not produce an additional benefit beyond that provided by CRL42796 alone.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Coronary artery thrombosis was inhibited in four of five vessels treated with the lower infusion dose of CRL42796 and in five of five vessels treated with the higher infusion. Time to thrombosis increased with both doses (Control, 90.8\u00b110.4 min; low dose, 165.8\u00b114.2 min; high dose, &gt;180.0\u00b10 min).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The results indicate that CRL42796 is an effective <jats:italic>in vivo<\/jats:italic> antithrombotic agent against experimentally\u2010induced carotid and coronary artery thrombosis.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2002) <jats:bold>136<\/jats:bold>, 927\u2013937. doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0704744\">10.1038\/sj.bjp.0704744<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0704744","type":"journal-article","created":{"date-parts":[[2002,7,28]],"date-time":"2002-07-28T21:36:01Z","timestamp":1027892161000},"page":"927-937","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prevention of experimental carotid and coronary artery thrombosis by the glycoprotein IIb\/IIIa receptor antagonist CRL42796"],"prefix":"10.1111","volume":"136","author":[{"given":"James K","family":"Hennan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting\u2010Ting","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E","family":"Willens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward M","family":"Driscoll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry A","family":"Giboulot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedict R","family":"Lucchesi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019501-199201000-00010"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.1096\/fasebj.4.13.2210155","article-title":"In vivo models of arterial thrombosis and thrombolysis","volume":"4","author":"BUSH L.R.","year":"1990","journal-title":"FASEB J."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1002658"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(99)70339-X"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-10-199905180-00019"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc3301.092790"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(98)00912-1"},{"key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"5649","DOI":"10.1016\/S0021-9258(18)42815-3","article-title":"Isolation and characterization of a chymotryptic fragment of platelet glycoprotein IIb\/IIIa retaining Arg\u2010Gly\u2010Asp binding activity","volume":"267","author":"LAM S.C.","year":"1992","journal-title":"J. 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