{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T13:34:46Z","timestamp":1760621686248},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,2,2]],"date-time":"2009-02-02T00:00:00Z","timestamp":1233532800000},"content-version":"vor","delay-in-days":2438,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>In conscious, freely\u2010moving, male, Sprague\u2010Dawley rats, the regional haemodynamic responses to the synthetic cannabinoids, WIN\u201055212\u20102 and HU\u2003210, were compared. The possible involvement of cannabinoid, CB<jats:sub>1<\/jats:sub>\u2010receptors, or \u03b2<jats:sub>2<\/jats:sub>\u2010adrenoceptors in the responses to WIN\u201055212\u20102 and HU\u2003210 were investigated using the CB<jats:sub>1<\/jats:sub>\u2010receptor antagonist, AM\u2003251, or the \u03b2<jats:sub>2<\/jats:sub>\u2010adrenoceptor antagonist, ICI\u2003118551, respectively.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Both WIN\u201055212\u20102 (150\u2003\u03bcg\u2003kg<jats:sup>\u22121<\/jats:sup>) and HU\u2003210 (100\u2003\u03bcg\u2003kg<jats:sup>\u22121<\/jats:sup>) had pressor, renal, and mesenteric vasoconstrictor and hindquarters vasodilator actions, although the effects of HU\u2003210 were much more sustained than those of WIN\u201055212\u20102. Lower doses of the cannabinoids (WIN\u201055212\u20102, 50\u2003\u03bcg\u2003kg<jats:sup>\u22121<\/jats:sup>, HU\u2003210, 10\u2003\u03bcg\u2003kg<jats:sup>\u22121<\/jats:sup>) had less consistent actions.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>All the significant cardiovascular effects of WIN\u201055212\u20102 and HU\u2003210 were antagonized by pretreatment with AM\u2003251 (3\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>). Furthermore, pretreatment with the \u03b2<jats:sub>2<\/jats:sub>\u2010adrenoceptor antagonist, ICI\u2003118551, inhibited the hindquarters vasodilator effects of WIN\u201055212\u20102 and of HU\u2003210.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>On the basis of the present findings, and our earlier work, it is suggested that, in conscious rats, the pressor and vasoconstrictor effects of HU\u2003210 and WIN\u201055212\u20102 involve cannabinoid\u2010receptor\u2010mediated increases in sympathetic activity. The accompanying hindquarters vasodilator actions of these agonists are cannabinoid receptor\u2010mediated and appear to involve \u03b2<jats:sub>2<\/jats:sub>\u2010adrenoceptors.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2002) <jats:bold>136<\/jats:bold>, 581\u2013587; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0704750\">10.1038\/sj.bjp.0704750<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0704750","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T22:11:23Z","timestamp":1106950283000},"page":"581-587","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Influence of the CB<sub>1<\/sub> receptor antagonist, AM\u2003251, on the regional haemodynamic effects of WIN\u201055212\u20102 or HU\u2003210 in conscious rats"],"prefix":"10.1111","volume":"136","author":[{"given":"S M","family":"Gardiner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J E","family":"March","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P A","family":"Kemp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-198305000-00013"},{"key":"e_1_2_6_3_1","first-page":"H813","article-title":"Regional haemodynamic responses to adrenoceptor antagonism in conscious rats","volume":"255","author":"GARDINER S.M.","year":"1988","journal-title":"Am. 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