{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T03:31:07Z","timestamp":1789097467608,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,2,2]],"date-time":"2009-02-02T00:00:00Z","timestamp":1233532800000},"content-version":"vor","delay-in-days":2438,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>The inhibitory effects of n\u2010alcohols (methanol to dodecanol) on glycine\u2010activated currents were studied in neurons freshly dissociated from the ventral tegmental area of neonatal rats using whole\u2010cell patch\u2010clamp recording technique.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Ethanol enhanced and depressed glycine\u2010activated currents in 35% and 45%, respectively, of neurons of ventral tegmental area of neonatal rats. In this report, we extended our focus of ethanol\u2010induced inhibition of glycine currents to other straight\u2010chain alcohols.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Aliphatic n\u2010alcohols, which have carbon numbers less than nine, suppressed glycine currents in 45% (71\/158) of the neurons. All results from this study are obtained from the 45% of cells displaying inhibition; the other 55% of the neurons were not studied.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Alcohol potency increased as the number of carbon atoms increased from one to five, and was at a maximal plateau from five to nine; alcohols with 10 or more carbons did not inhibit glycine\u2010activated currents. Thus, a \u2018cutoff\u2019 point in their potency for inhibition of glycine receptor function occurred at about decanol.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>A coapplication of dodecanol with ethanol eliminated the inhibition resulting from ethanol. Thus, dodecanol may bind to the receptor silently and compete with ethanol.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These observations indicate that straight\u2010chain n\u2010alcohols exhibit a \u2018cutoff\u2019 point in their potency for inhibition of the glycine receptor function between nine and 10 carbon atoms. The inability of longer alcohols to change the activation properties of the receptors may contribute to the cutoff effect.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2002) <jats:bold>136<\/jats:bold>, 629\u2013635; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0704775\">10.1038\/sj.bjp.0704775<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0704775","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T22:11:23Z","timestamp":1106950283000},"page":"629-635","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Inhibition of glycine receptor function of native neurons by aliphatic n\u2010alcohols"],"prefix":"10.1111","volume":"136","author":[{"given":"Liang","family":"Tao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang Hong","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,2,2]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"61","article-title":"Ethanol modulation of the \u03b3\u2010aminobutyric acidA\u2010 and glycine\u2010activated Cl\u2212 currents in cultured mouse neurons","volume":"270","author":"AGUAYO L.G.","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704112"},{"key":"e_1_2_7_4_1","first-page":"3","article-title":"Axoscope junction potential calculator","volume":"18","author":"BARRY P.","year":"1996","journal-title":"Axobits"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(91)90045-V"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb11343.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1999.tb04082.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(88)90098-4"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(91)90003-D"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2159183"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15413.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1991.tb03764.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0741-8329(94)90083-3"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5455.1056"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15314.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.5560060206"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410150107"},{"key":"e_1_2_7_18_1","first-page":"2715","article-title":"Cellular and molecular mechanisms of drug dependence","volume":"24","author":"KOOB G.F.","year":"1988","journal-title":"Science"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-75-5-439"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1990.tb19419.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.17.8200"},{"key":"e_1_2_7_22_1","first-page":"263","article-title":"Ethanol potentiation of 5\u2010hydroxytryptamine3 receptor\u2010mediated ion current in neuroblastoma cells and isolated adult mammalian neurons","volume":"40","author":"LOVINGER D.M.","year":"1991","journal-title":"Mol. Pharmacol."},{"key":"e_1_2_7_23_1","first-page":"669","article-title":"A relationship between alcohol intoxication and the disordering of brain membranes by a series of short\u2010chain alcohols","volume":"218","author":"LYON R.C.","year":"1981","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_7_24_1","first-page":"898","article-title":"Alcohols and anesthetics enhance the function of 5\u2010hydroxytryptamine3 receptors expressed in Xenopus laevis oocytes","volume":"271","author":"MACHU T.K.","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb16042.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(78)90050-3"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1995.tb15874.x"},{"key":"e_1_2_7_28_1","first-page":"7A","article-title":"Potentiation of GABAergic currents by a series of alcohols: studies of receptor composition and the cut\u2010off phenomenon","volume":"19","author":"MIHIC S.J.","year":"1995","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.3.1084"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1991.sp018604"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.61.1.169"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.7.2825"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199901180-00019"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.36.040196.001153"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199305000-00017"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1994.sp020142"},{"key":"e_1_2_7_37_1","first-page":"718","article-title":"Inhibition of nicotinic receptors by Bis (2,2,6,6\u2010tetramethyl\u20104\u2010piperidinyl) sebacate (Tinuvin 770), an additive to medical plastics","volume":"268","author":"ROGER L.","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/364082a0"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1994.62051783.x"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.300.3.967"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1968.31.1.81"},{"key":"e_1_2_7_42_1","doi-asserted-by":"crossref","first-page":"6504","DOI":"10.1073\/pnas.95.11.6504","article-title":"Mutations of gamma\u2010aminobutyric acid and glycine receptors change alcohol cutoff: evidence for an alcohol receptor","volume":"95","author":"WICK M.J.","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.19.030196.001535"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02073-4"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00317-5"},{"key":"e_1_2_7_46_1","first-page":"77","article-title":"Ethanol potentiation of glycine\u2010induced responses in dissociated neurons of rat ventral tegmental area","volume":"296","author":"YE J.H.","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2001.86.5.2426"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.bjp.0704775","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.bjp.0704775","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/sj.bjp.0704775","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T13:52:38Z","timestamp":1697550758000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1038\/sj.bjp.0704775"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,6]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,6]]}},"alternative-id":["10.1038\/sj.bjp.0704775"],"URL":"https:\/\/doi.org\/10.1038\/sj.bjp.0704775","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,6]]},"assertion":[{"value":"2009-02-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}