{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T20:05:52Z","timestamp":1771617952883,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2009,2,2]],"date-time":"2009-02-02T00:00:00Z","timestamp":1233532800000},"content-version":"vor","delay-in-days":2377,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2002,8]]},"abstract":"<jats:p>Endothelium\u2010dependent responses were assessed in myometrial small arteries isolated from pregnant women, using pressure myography. Responses to bradykinin were unaffected by the combined presence of the nitric oxide synthase (NOS) inhibitor, <jats:italic>N<\/jats:italic>\u2010nitro\u2010<jats:sc>L<\/jats:sc>\u2010arginine methyl ester (<jats:sc>L<\/jats:sc>\u2010NAME, 100 \u03bc<jats:sc>M<\/jats:sc>) and the cyclo\u2010oxygenase inhibitor, indomethacin (10 \u03bc<jats:sc>M<\/jats:sc>). The additional presence of clotrimazole (50 \u03bc<jats:sc>M<\/jats:sc>) attenuated, but did not abolish, vasodilator responses to bradykinin. Raising extracellular [K<jats:sup>+<\/jats:sup>] (by between 1 and 15 m<jats:sc>M<\/jats:sc>) did not evoke a vasodilator response, nor did the cannabinoids, anandamide and methanandamide. Responses to bradykinin were attenuated in the presence of the gap junction inhibitors 18\u2010\u03b1\u2010glycyrrhetinic acid (18\u2010\u03b1 GA, 100 \u03bc<jats:sc>M<\/jats:sc>), carbenoxolone (100 \u03bc<jats:sc>M<\/jats:sc>) and palmitoleic acid (50 \u03bc<jats:sc>M<\/jats:sc>). SR141716A, the CB<jats:sub>1<\/jats:sub> receptor antagonist attenuated responses to bradykinin, but only at high concentrations (10 \u03bc<jats:sc>M<\/jats:sc>). These results suggest that gap junctional communication is involved in the nitric oxide (NO)\u2010 and prostanoid\u2010independent vasodilator responses to bradykinin in myometrial small arteries in normal pregnancy.<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2002) <jats:bold>136<\/jats:bold>, 1085\u20131088. doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0704817\">10.1038\/sj.bjp.0704817<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0704817","type":"journal-article","created":{"date-parts":[[2002,9,18]],"date-time":"2002-09-18T00:15:48Z","timestamp":1032308148000},"page":"1085-1088","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["The role of gap junctions in mediating endothelium\u2010dependent responses to bradykinin in myometrial small arteries isolated from pregnant women"],"prefix":"10.1111","volume":"136","author":[{"given":"Louise C","family":"Kenny","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip N","family":"Baker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A","family":"Kendall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D","family":"Randall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William R","family":"Dunn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703041"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.78.3.415"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.561bq.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.00539.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.12.1702"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.0359i.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/24388"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703009"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00512-4"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2001.013489"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs1030067"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701066"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI557"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1996.1766"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2002.282.1.H335"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702078"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.27.12.2287"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15517.x"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.bjp.0704817","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.bjp.0704817","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/sj.bjp.0704817","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T14:40:17Z","timestamp":1697553617000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1038\/sj.bjp.0704817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,8]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2002,8]]}},"alternative-id":["10.1038\/sj.bjp.0704817"],"URL":"https:\/\/doi.org\/10.1038\/sj.bjp.0704817","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,8]]},"assertion":[{"value":"2009-02-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}