{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:55:22Z","timestamp":1791352522896,"version":"4.3.1"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,2,2]],"date-time":"2009-02-02T00:00:00Z","timestamp":1233532800000},"content-version":"vor","delay-in-days":2316,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2002,10]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item>\n<jats:p>To evaluate the role of prostaglandin I<jats:sub>2<\/jats:sub> (PGI<jats:sub>2<\/jats:sub>) in allergic inflammation, allergic responses in the airway, skin and T cells were studied in mice lacking the receptor for PGI<jats:sub>2<\/jats:sub> (the prostanoid IP receptor) through gene disruption.<\/jats:p>\n<\/jats:list-item>\n<jats:list-item>\n<jats:p>Three inhalations of antigen caused an increase in plasma extravasation, leukocyte accumulation and cytokine (interleukin (IL)\u20104 and IL\u20105) production in the airway of sensitized mice. These airway inflammatory responses were significantly greater in IP receptor deficient mice than in wild\u2010type mice.<\/jats:p>\n<\/jats:list-item>\n<jats:list-item>\n<jats:p>The vascular leakage caused by passive cutaneous anaphylaxis, substance P and 5\u2010hydroxytryptamine was markedly increased in the skin of IP receptor deficient mice, compared with comparably treated wild\u2010type mice.<\/jats:p>\n<\/jats:list-item>\n<jats:list-item>\n<jats:p>The inhalation of antigen in sensitized mice resulted in increased serum antigen specific IgE, total IgE and IgG levels. The magnitude of the elevations of each immunoglobulin level in IP receptor deficient mice is notably higher than that in wild\u2010type mice. To elucidate the mechanism of an enhancement of immunoglobulin production, the activity of T cells in sensitized and non\u2010sensitized mice was studied by means of the production of cytokines. The antigen\u2010induced IL\u20104 production by spleen cells from sensitized IP receptor deficient mice was almost three times greater than that in wild\u2010type mice. On the contrary, the anti\u2010CD3 antibody\u2010induced interferon\u2010\u03b3 production by CD4<jats:sup>+<\/jats:sup> T cells from non\u2010sensitized IP receptor deficient mice was significantly lower than that in wild\u2010type mice.<\/jats:p>\n<\/jats:list-item>\n<jats:list-item>\n<jats:p>The present data indicate that IP receptor deficiency reinforced an allergic airway and skin inflammation by augmentation of vascular permeability increase and the T helper 2 cell function. These findings suggest a regulatory role of PGI<jats:sub>2<\/jats:sub> in allergic inflammation.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2002) <jats:bold>137<\/jats:bold>, 315\u2013322. doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0704872\">10.1038\/sj.bjp.0704872<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0704872","type":"journal-article","created":{"date-parts":[[2002,9,17]],"date-time":"2002-09-17T18:11:23Z","timestamp":1032286283000},"page":"315-322","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":101,"title":["Augmentation of allergic inflammation in prostanoid IP receptor deficient mice"],"prefix":"10.1111","volume":"137","author":[{"given":"Yoshimasa","family":"Takahashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shota","family":"Tokuoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taisei","family":"Masuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousuke","family":"Hirano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Nagao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Inagaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuh","family":"Narumiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroichi","family":"Nagai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,2,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-200009000-00006"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.146.1.108"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1977.tb07564.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2000.00880.x"},{"key":"e_1_2_6_6_1","first-page":"601","volume-title":"The Pharmacological Basis of Therapeutics","author":"CAMPBELL W.B.","year":"1996"},{"key":"e_1_2_6_7_1","first-page":"643","volume-title":"Comprehensive Medicinal Chemistry","author":"COLEMAN R.A.","year":"1989"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.6.1712"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1986.tb10161.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00914313"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.1.9804030"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI6890"},{"key":"e_1_2_6_13_1","first-page":"802","article-title":"Cyclooxygenase\u20102\u2010mediated angiogenesis in carrageenin\u2010induced granulation tissue in rats","volume":"295","author":"GHOSH A.K.","year":"2000","journal-title":"J. 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