{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T13:31:04Z","timestamp":1762954264303},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,2,2]],"date-time":"2009-02-02T00:00:00Z","timestamp":1233532800000},"content-version":"vor","delay-in-days":2285,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Vasodilatation in the dura mater has been suggested to play an important role in the pathophysiology of vascular headaches. Histamine may contribute to these vascular changes. The aim of the present study was to examine the role of different histamine receptors in histamine\u2010induced meningeal hyperperfusion using laser Doppler flowmetry.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The blood flow in the medial meningeal artery was monitored in the exposed parietal dura mater encephali of barbiturate anaesthetized rats. Local application of histamine (10<jats:sup>\u22125<\/jats:sup> and 10<jats:sup>\u22124<\/jats:sup> <jats:sc>M<\/jats:sc>) onto the dura caused increases in flow to 114.2\u00b19.6 and 135.1\u00b119.1%, respectively, of the basal flow.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Flow increases induced by topical application of histamine (10<jats:sup>\u22124<\/jats:sup> <jats:sc>M<\/jats:sc>) were reduced by local pretreatment with the H<jats:sub>2<\/jats:sub>\u2010receptor antagonist cimetidine (0.4 and 4 m<jats:sc>M<\/jats:sc>) to 63.4\u00b117 and 37.8\u00b118.8%, respectively. Systemic pre\u2010administration of cimetidine (5 mg kg<jats:sup>\u22121<\/jats:sup> i.v.) did not change histamine\u2010induced flow increases.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Local pretreatment with the H<jats:sub>1<\/jats:sub>\u2010receptor antagonist cetirizine (2 \u03bc<jats:sc>M<\/jats:sc>) further increased the flow evoked by topical histamine administration (10<jats:sup>\u22124<\/jats:sup> <jats:sc>M<\/jats:sc>) to 123.5\u00b114.7% of the histamine control.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Increases in blood flow induced by i.v. administration of histamine (10 \u03bcg kg<jats:sup>\u22121<\/jats:sup>) were reduced by i.v. pre\u2010injection of cetirizine (50 \u03bcg kg<jats:sup>\u22121<\/jats:sup>) to 31.9\u00b19% but not by i.v. cimetidine (5 mg kg<jats:sup>\u22121<\/jats:sup>).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>We conclude that histamine\u2010induced relaxation of dural arterial vessels is mediated by H<jats:sub>2<\/jats:sub>\u2010receptors, most likely located on vascular smooth muscle cells, and by endothelial H<jats:sub>1<\/jats:sub>\u2010receptors. In addition, H<jats:sub>1<\/jats:sub>\u2010receptors on smooth muscle cells may mediate vasoconstriction.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2002) <jats:bold>137<\/jats:bold>, 874\u2013880. doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0704946\">10.1038\/sj.bjp.0704946<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0704946","type":"journal-article","created":{"date-parts":[[2002,11,1]],"date-time":"2002-11-01T05:21:57Z","timestamp":1036128117000},"page":"874-880","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Possible role of histamine (H<sub>1<\/sub>\u2010 and H<sub>2<\/sub>\u2010) receptors in the regulation of meningeal blood flow"],"prefix":"10.1111","volume":"137","author":[{"given":"M\u00e1ria","family":"Dux","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Schwenger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl","family":"Messlinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199101000-00013"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199401120-00039"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1936.02260050128008"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000115100"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1988.59.2.648"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(91)90253-K"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(90)90234-U"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01252276"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00366-2"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410280213"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1982.tb01633.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1994.25"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701097"},{"key":"e_1_2_7_15_1","first-page":"129","volume-title":"The Histamine Receptor","author":"JOHNSON C.L.","year":"1992"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(95)00162-X"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90012-7"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1995.tb13361.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199507310-00003"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.11.5.469"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(92)90798-9"},{"key":"e_1_2_7_22_1","first-page":"281","article-title":"Nitric oxide but not histamine increases meningeal blood flow by release of calcitonin gene\u2010related peptide","volume":"20","author":"MESSLINGER K.","year":"2000","journal-title":"Cephalalgia"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703220"},{"key":"e_1_2_7_24_1","first-page":"S16","article-title":"Neurogenic inflammation in the pathophysiology and treatment of migraine","volume":"43","author":"MOSKOWITZ M.A.","year":"1993","journal-title":"Neurology"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1997.1703166.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1991.1104183.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.1999.00038.x"},{"key":"e_1_2_7_28_1","first-page":"77","article-title":"Observations on the mechanisms of headache produced by histamine","volume":"1","author":"PICKERING G.W.","year":"1933","journal-title":"Clin. Sci."},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1940.01210040002001"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.42.7.668"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1997.1703175.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1358\/mf.1999.21.9.795613","article-title":"Effects of histamine and related compounds on regional cerebral blood flow in rats","volume":"21","author":"SUZUKI G.","year":"1999","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1997.1708873.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.1994.tb00053.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1971.34.5.0630"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.bjp.0704946","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.bjp.0704946","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/sj.bjp.0704946","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T12:22:52Z","timestamp":1697545372000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1038\/sj.bjp.0704946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,11]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2002,11]]}},"alternative-id":["10.1038\/sj.bjp.0704946"],"URL":"https:\/\/doi.org\/10.1038\/sj.bjp.0704946","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,11]]},"assertion":[{"value":"2009-02-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}