{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T17:51:32Z","timestamp":1782409892630,"version":"3.54.5"},"reference-count":49,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,2,2]],"date-time":"2009-02-02T00:00:00Z","timestamp":1233532800000},"content-version":"vor","delay-in-days":2255,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>A novel immunosuppressant FTY720 caused a significant decrease in peripheral T lymphocytes, but not in B lymphocytes upon oral administration. This decrease was mainly a result of FTY720\u2010induced apoptosis. In this study, we confirmed FTY720\u2010induced T cell selective apoptosis using lymphoma cell lines <jats:italic>in vitro<\/jats:italic>.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Viability loss, DNA fragmentation, Annexin V binding, and caspases activation (caspase\u20103, \u20108, and \u20109) were observed in Jurkat cells (T lymphoma cells), but not significantly in BALL\u20101 cells (B lymphoma cells). These results indicated that FTY720 selectively induced apoptosis in T cell lymphoma to a greater extent than in B cell lymphoma, a finding that is similar to the result observed when FTY720 was treated with T lymphocytes and B lymphocytes <jats:italic>in vitro<\/jats:italic>.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>FTY720 released cytochrome <jats:italic>c<\/jats:italic> from mitochondria in Jurkat intact cells as well as from isolated Jurkat mitochondria directly, but not from mitochondria in BALL\u20101 cells nor from isolated BALL\u20101 mitochondria.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>BALL\u20101 cells and B cells had more abundant mitochondria\u2010localized anti\u2010apoptotic protein Bcl\u20102 than did Jurkat cells and T cells.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>FTY720\u2010induced apoptosis is inhibited by the overexpression of Bcl\u20102, suggesting that the cellular Bcl\u20102 level regulates the sensitivity to FTY720.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2002) <jats:bold>137<\/jats:bold>, 953\u2013962. doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0704970\">10.1038\/sj.bjp.0704970<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0704970","type":"journal-article","created":{"date-parts":[[2002,11,12]],"date-time":"2002-11-12T18:47:25Z","timestamp":1037126845000},"page":"953-962","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["T cell selective apoptosis by a novel immunosuppressant, FTY720, is closely regulated with Bcl\u20102"],"prefix":"10.1111","volume":"137","author":[{"given":"Yukitoshi","family":"Nagahara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Ikekita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahisa","family":"Shinomiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,2,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428199409051655"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(93)90181-J"},{"key":"e_1_2_7_4_1","first-page":"336","article-title":"A review of clinical experience with the novel immunosuppressive drug mycophenolate mofetil in renal transplantation","volume":"45","author":"BEHREND M.","year":"1996","journal-title":"Clin. 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