{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:44:11Z","timestamp":1790981051633,"version":"4.1.0"},"reference-count":66,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":2251,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item>\n<jats:p>The presynaptic interactions between facilitatory \u03b2\u2010adrenoreceptors and inhibitory 5\u2010hydroxytryptamine (5\u2010HT) receptors modulating glutamate release from cerebrocortical nerve terminals were examined.<\/jats:p>\n<\/jats:list-item>\n<jats:list-item>\n<jats:p>4\u2010Aminopyridine (4\u2010AP, 1 m<jats:sc>M<\/jats:sc>)\u2010evoked glutamate release was facilitated by the membrane permeant cyclic\u20103\u2032,5\u2032\u2010adenosine monophosphate (cAMP) analogue, 8\u2010bromo\u2010cAMP (8\u2010Br\u2010cAMP), used to directly activate cAMP\u2010dependent protein kinase (PKA).<\/jats:p>\n<\/jats:list-item>\n<jats:list-item>\n<jats:p>The \u03b2\u2010adrenoreceptor agonist, isoprenaline (ISO), effected a concentration\u2010dependent potentiation of 4\u2010AP\u2010evoked glutamate release which was abolished by the \u03b2\u2010adrenoreceptor antagonist, propranolol, and the PKA inhibitor, Rp\u2010cyclic\u20103\u2032,5\u2032\u2010adenosine\u2010monophosphothioate (Rp\u2010cAMPS).<\/jats:p>\n<\/jats:list-item>\n<jats:list-item>\n<jats:p>5\u2010HT receptor activation by 100 \u03bc<jats:sc>M<\/jats:sc> 5\u2010HT produced an inhibition of 4\u2010AP\u2010evoked glutamate release in nerve terminals. The inhibitory effect of 5\u2010HT could be mimicked by the selective 5\u2010HT<jats:sub>1A<\/jats:sub> receptor agonist, 8\u2010hydroxy\u2010dipropylaminotetralin (8\u2010OH\u2010DPAT) and antagonized by 1\u2010(2\u2010methoxyphenyl)\u20104\u2010(4\u2010phthalimidobutyl)piperazine (NAN\u2010190).<\/jats:p>\n<\/jats:list-item>\n<jats:list-item>\n<jats:p>When 5\u2010HT (or 8\u2010OH\u2010DPAT) was used in conjunction with ISO or 8\u2010Br\u2010cAMP, the \u03b2\u2010adrenoreceptor\u2010 and PKA\u2010mediated potentiation of glutamate release was abrogated.<\/jats:p>\n<\/jats:list-item>\n<jats:list-item>\n<jats:p>The inhibitory crosstalk of 5\u2010HT<jats:sub>1A<\/jats:sub> receptors to \u03b2\u2010adrenoceptor\u2010mediated facilitation of glutamate release was abolished in the presence of NAN\u2010190.<\/jats:p>\n<\/jats:list-item>\n<jats:list-item>\n<jats:p>Examination of voltage\u2010dependent Ca<jats:sup>2+<\/jats:sup> influx revealed that, while ISO and 5\u2010HT alone caused a respective potentiation and diminution of the 4\u2010AP\u2010evoked increase in [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>c<\/jats:sub>, the co\u2010presence of 5\u2010HT abolished the ISO mediated potentiation of Ca<jats:sup>2+<\/jats:sup> influx.<\/jats:p>\n<\/jats:list-item>\n<jats:list-item>\n<jats:p>Together, these results suggest that \u03b2\u2010adrenoreceptors and 5\u2010HT<jats:sub>1A<\/jats:sub> receptors coexist on the cerebrocortical nerve terminals and that the cross\u2010talk between the two receptor signalling pathways occurs at a locus downstream from cAMP production, possibly at the level of voltage\u2010dependent Ca<jats:sup>2+<\/jats:sup> influx.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2002) <jats:bold>137<\/jats:bold>, 1371\u20131379. doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0705045\">10.1038\/sj.bjp.0705045<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0705045","type":"journal-article","created":{"date-parts":[[2002,12,4]],"date-time":"2002-12-04T18:22:03Z","timestamp":1039026123000},"page":"1371-1379","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Presynaptic cross\u2010talk of \u03b2\u2010adrenoreceptor and 5\u2010hydroxytryptamine receptor signalling in the modulation of glutamate release from cerebrocortical nerve terminals"],"prefix":"10.1111","volume":"137","author":[{"given":"Su\u2010Jane","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Coutinho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talvinder S","family":"Sihra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1991.tb08306.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1997.77.3.1362"},{"key":"e_1_2_7_4_1","first-page":"37","article-title":"Serotonin agonists inhibit synaptic potentials in the rat locus ceruleus in vitro via 5\u2010hydroxytryptamine 1A and 5\u2010hydroxytryptamine 1B receptors","volume":"250","author":"BOBKER D.H.","year":"1989","journal-title":"J. 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