{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T08:49:01Z","timestamp":1766047741596},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,2,2]],"date-time":"2009-02-02T00:00:00Z","timestamp":1233532800000},"content-version":"vor","delay-in-days":2224,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:p>The effects of the anti\u2010relapse compound acamprosate (calcium acetylhomotaurinate) on the conditioned rewarding effects of ethanol, cocaine and morphine were studied using the conditioned place preference (CPP) paradigm. During 3 days of drug conditioning, mice were pretreated with saline or acamprosate (30, 100 or 300 mg kg<jats:sup>\u22121<\/jats:sup> i.p.) 10 min prior to the administration of ethanol (2 g kg<jats:sup>\u22121<\/jats:sup> i.p.), cocaine (15 mg kg<jats:sup>\u22121<\/jats:sup> i.p.) or morphine (10 mg kg<jats:sup>\u22121<\/jats:sup> i.p.), and subsequently confined to one of two distinct conditioning chambers. On the following day, mice were tested for the expression of CPP. Acamprosate dose\u2010dependently reduced the development of CPP to ethanol and cocaine but not morphine. When tested as the conditioning drug, acamprosate alone produced neither a conditioned place preference nor aversion. These data suggest that acamprosate can suppress the conditioned rewarding effects of ethanol and certain classes of abused substances.<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2003) <jats:bold>138<\/jats:bold>, 9\u201312. doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0705059\">10.1038\/sj.bjp.0705059<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0705059","type":"journal-article","created":{"date-parts":[[2003,1,9]],"date-time":"2003-01-09T19:22:37Z","timestamp":1042140157000},"page":"9-12","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["The anti\u2010relapse compound acamprosate inhibits the development of a conditioned place preference to ethanol and cocaine but not morphine"],"prefix":"10.1111","volume":"138","author":[{"given":"Andrew J","family":"Mcgeehan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M Foster","family":"Olive","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,2]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"144","article-title":"Pharmacokinetics of systemically administered cocaine and locomotor stimulation in mice","volume":"243","author":"BENUCK M.","year":"1987","journal-title":"J. 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