{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T18:22:36Z","timestamp":1697221356047},"reference-count":54,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,1,30]],"date-time":"2009-01-30T00:00:00Z","timestamp":1233273600000},"content-version":"vor","delay-in-days":2162,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2003,3]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Various neurotransmitters in the brain regulate gastric acid secretion. Previously, we reported that the central injection of <jats:italic>\u03ba<\/jats:italic>\u2010opioid receptor agonists stimulated this secretion in rats. Although the existence of <jats:italic>\u03ba<\/jats:italic><jats:sub>1<\/jats:sub>\u2013<jats:italic>\u03ba<\/jats:italic><jats:sub>3<\/jats:sub>\u2010opioid receptor subtypes has been proposed, the character is not defined. We investigated the interactions between <jats:italic>\u03ba<\/jats:italic>\u2010opioid receptor subtypes and glutamate, <jats:italic>\u03b3<\/jats:italic>\u2010amino\u2010butyric acid (GABA) or 5\u2010hydroxy tryptamine (5\u2010HT) receptors in the rat brain.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Gastric acid secretion induced by the injection of U69593 (8.41 nmol, a putative <jats:italic>\u03ba<\/jats:italic><jats:sub>1<\/jats:sub>\u2010opioid receptor agonist) into the lateral cerebroventricle was completely inhibited by the central injection of 6\u2010cyano\u20107\u2010nitroquinoxaline\u20102,3\u2010dione (CNQX, 10.9 nmol, an antagonist for non\u2010<jats:italic>N<\/jats:italic>\u2010methyl\u2010<jats:sc>D<\/jats:sc>\u2010aspartate (non\u2010NMDA) receptors) and by bicuculline infusion (222 <jats:italic>\u03bc<\/jats:italic>g kg<jats:sup>\u22121<\/jats:sup> per 10 min, i.v., GABA<jats:sub>A<\/jats:sub> receptor antagonist). The secretion induced by bremazocine (8.52 nmol, a putative <jats:italic>\u03ba<\/jats:italic><jats:sub>2<\/jats:sub>\u2010opioid receptor agonist) was inhibited by bicuculline infusion, but not by CNQX. The secretion induced by naloxone benzoylhydrazone (224 nmol, a putative <jats:italic>\u03ba<\/jats:italic><jats:sub>3<\/jats:sub>\u2010opioid receptor agonist) was slightly and partially inhibited by CNQX and bicuculline.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Treatment with CNQX and bicuculline inhibited gastric acid secretion induced by the injection of dynorphin A\u2010(1\u201017) into the lateral, but not the fourth, cerebroventricle. Antagonists for NMDA, GABA<jats:sub>B<\/jats:sub> and 5\u2010HT<jats:sub>2\/1C<\/jats:sub> receptors did not inhibit the secretions by <jats:italic>\u03ba<\/jats:italic>\u2010opioid receptor agonists.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In rat brain regions close to the lateral cerebroventricle, <jats:italic>\u03ba<\/jats:italic>\u2010opioid receptor systems (<jats:italic>\u03ba<\/jats:italic><jats:sub>1<\/jats:sub>&gt;<jats:italic>\u03ba<\/jats:italic><jats:sub>3<\/jats:sub>\u226b<jats:italic>\u03ba<\/jats:italic><jats:sub>2<\/jats:sub>) are regulated by the non\u2010NMDA type of glutamate receptor system, and <jats:italic>\u03ba<\/jats:italic><jats:sub>1<\/jats:sub>\u2010 and <jats:italic>\u03ba<\/jats:italic><jats:sub>2<\/jats:sub>\u2010opioid receptor systems are regulated by the GABA<jats:sub>A<\/jats:sub> receptor system. The present findings show pharmacological evidence for <jats:italic>\u03ba<\/jats:italic>\u2010opioid receptor subtypes that regulate gastric acid secretion in the rat brain.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2003) <jats:bold>138<\/jats:bold>, 1049\u20131058. doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0705082\">10.1038\/sj.bjp.0705082<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0705082","type":"journal-article","created":{"date-parts":[[2003,4,8]],"date-time":"2003-04-08T17:04:06Z","timestamp":1049821446000},"page":"1049-1058","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Involvement of glutamate and <i>\u03b3<\/i>\u2010amino\u2010butyric acid receptor systems on gastric acid secretion induced by activation of <i>\u03ba<\/i>\u2010opioid receptors in the central nervous system in rats"],"prefix":"10.1111","volume":"138","author":[{"given":"Sachie","family":"Minowa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satomi","family":"Ishihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shizuko","family":"Tsuchiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syunji","family":"Horie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiko","family":"Murayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"3793","DOI":"10.1523\/JNEUROSCI.10-12-03793.1990","article-title":"Dynorphin A\u2010(1\u201017) induces alternations in free fatty acids excitatory amino acids and motor function through an opiate\u2010receptor\u2010mediated mechanism","volume":"10","author":"BAKSHI R.","year":"1990","journal-title":"J. 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