{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T02:53:10Z","timestamp":1772074390564,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,1,30]],"date-time":"2009-01-30T00:00:00Z","timestamp":1233273600000},"content-version":"vor","delay-in-days":2162,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2003,3]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Melatonin is involved in the control of intraocular pressure during the night and day photoperiod. We have investigated the receptor that regulates intraocular pressure in New Zealand white rabbits by means of agonists and antagonists of melatonin receptors.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Melatonin and its analogues: 2\u2010Phe\u2010melatonin, 6\u2010Cl\u2010melatonin, 2\u2010I\u2010melatonin, 5\u2010 methoxycarbonylamino\u2010<jats:italic>N<\/jats:italic>\u2010acetyltryptamine (5\u2010MCA\u2010NAT) and <jats:italic>N<\/jats:italic>\u2010acetyltryptamine all produced a reduction in intraocular pressure. Dose\u2010response analysis for these compounds gave pD<jats:sub>2<\/jats:sub> values of 9.3\u00b10.24 for melatonin; 9.0\u00b10.09 for 6\u2010Cl\u2010melatonin; 9.0\u00b10.84 for 2\u2010I\u2010melatonin; 8.9\u00b10.07 for 5\u2010MCA\u2010NAT; 8.7\u00b10.18 for 2\u2010Phe\u2010melatonin and 9.4\u00b10.30 for <jats:italic>N<\/jats:italic>\u2010acetyltryptamine (all <jats:italic>n<\/jats:italic>=8).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>At a dose of 0.5 nmol (in 10 \u03bcl) melatonin and the selective melatonin MT<jats:sub>3<\/jats:sub> agonist 5\u2010MCA\u2010NAT, induced greater reductions of intraocular pressure (22.8\u00b12.3% and 32.5\u00b11.4%, respectively) than the other compounds.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The melatonin\u2010receptor antagonists, prazosin, DH\u201097 and 4\u2010P\u2010PDOT, reversed the effect of 5\u2010MCA\u2010NAT in a dose\u2010dependent manner, with pA<jats:sub>2<\/jats:sub> values of 13.5\u00b10.17 for prazosin, 10.6\u00b10.16 for DH\u201097 and 9.4\u00b10.20 for 4\u2010P\u2010PDOT (<jats:italic>n<\/jats:italic>=8).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Cholinoceptor antagonists (hexamethonium and atropine) and \u03b1<jats:sub>2<\/jats:sub>\u2010 and \u03b2<jats:sub>2<\/jats:sub>\u2010adrenoceptor antagonists (yohimbine and ICI 118,551) partially reversed the effects produced by melatonin and 5\u2010MCA\u2010NAT, suggesting the possible involvement of cholinergic and noradrenergic systems in the hypotensive actions mediated by melatonin agonists. The \u03b1<jats:sub>1<\/jats:sub>\u2010adrenoceptor antagonist, corynanthine, had no significant effect.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The strong hypotensive effect of the MT<jats:sub>3<\/jats:sub> agonist, 5\u2010MCA\u2010NAT, suggests that this compound may be a useful agent for treating those pathologies where intraocular pressure is abnormally elevated.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2003) <jats:bold>138<\/jats:bold>, 831\u2013836. doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0705118\">10.1038\/sj.bjp.0705118<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0705118","type":"journal-article","created":{"date-parts":[[2003,3,17]],"date-time":"2003-03-17T18:23:15Z","timestamp":1047925395000},"page":"831-836","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":89,"title":["Ocular hypotensive effects of melatonin receptor agonists in the rabbit: further evidence for an MT<sub>3<\/sub> receptor"],"prefix":"10.1111","volume":"138","author":[{"given":"Jesus","family":"Pintor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Pel\u00e1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles H V","family":"Hoyle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Assumpta","family":"Peral","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01953051"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.1990.tb00709.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1991.tb03443.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(96)00372-3"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1076\/ceyr.23.2.144.5480"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/exer.1999.0694"},{"key":"e_1_2_7_8_1","first-page":"348","article-title":"Insomnia in older individuals: is early morning awakening the main problem","volume":"26","author":"CUTLER N.L.","year":"1997","journal-title":"Sleep Res."},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-0186(92)90166-O"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(00)88978-6"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)91681-6"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/02713689109024135"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701287"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/112067219200200203"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0898-6568(96)00137-4"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M005141200"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(01)00615-3"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1006\/exer.1994.1076"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01992-7"},{"key":"e_1_2_7_20_1","first-page":"334","article-title":"Characterization of 2\u2010[125I]iodomelatonin binding sites in Syrian hamster peripheral organs","volume":"290","author":"PAUL P.","year":"1999","journal-title":"J. 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