{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:58:16Z","timestamp":1791158296315,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,1,30]],"date-time":"2009-01-30T00:00:00Z","timestamp":1233273600000},"content-version":"vor","delay-in-days":2162,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2003,3]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>UNC\u201049B and UNC\u201049C are \u03b3\u2010aminobutyric acid (GABA) receptor subunits encoded by the <jats:italic>Caenorhabditis elegans unc\u201049<\/jats:italic> gene. UNC\u201049B forms a homomeric GABA receptor, or can co\u2010assemble with UNC\u201049C to form a heteromeric receptor. The pharmacological properties of UNC\u201049B homomers and UNC\u201049B\/C heteromers were investigated in <jats:italic>Xenopus<\/jats:italic> oocytes.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The UNC\u201049 subunits are most closely related to the bicuculline\u2010 and benzodiazepine\u2010insensitive RDL GABA receptors of insects. Consistent with this classification, bicuculline (10 \u03bc<jats:sc>M<\/jats:sc>) did not inhibit, nor did diazepam (10 \u03bc<jats:sc>M<\/jats:sc>) enhance UNC\u201049B homomeric or UNC\u201049B\/C heteromeric receptors.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The UNC\u201049C subunit strongly affects the pharmacology of UNC\u201049B\/C heteromeric receptors. UNC\u201049B homomers were much more picrotoxin sensitive than UNC\u201049B\/C heteromers (IC<jats:sub>50<\/jats:sub>=0.9\u00b10.2 \u03bc<jats:sc>M<\/jats:sc> and 166\u00b142 \u03bc<jats:sc>M<\/jats:sc>, respectively). Pentobarbitone enhancement was greater for UNC\u201049B homomers compared to UNC\u201049B\/C heteromers. Propofol (50 \u03bc<jats:sc>M<\/jats:sc>) slightly enhanced UNC\u201049B homomers but slightly inhibited UNC\u201049B\/C heteromers. Penicillin G (10 m<jats:sc>M<\/jats:sc>) inhibited UNC\u201049B homomers less strongly than UNC\u201049B\/C heteromers (30% compared to 53% inhibition, respectively).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Several aspects of UNC\u201049 pharmacology were unusual. Picrotoxin sensitivity strongly correlates with dieldrin sensitivity, yet UNC\u201049B homomers were highly dieldrin resistant. The enhancing neurosteroid pregnanolone (5\u03b2\u2010pregnan\u20103\u03b1\u2010ol\u201020\u2010one; 10 \u03bc<jats:sc>M<\/jats:sc>) strongly inhibited both UNC\u201049 receptors. Alphaxalone (10 \u03bc<jats:sc>M<\/jats:sc>), another enhancing neurosteroid, did not affect UNC\u201049B homomers, but slightly inhibited UNC\u201049B\/C heteromers.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>UNC\u201049 subunits and mammalian GABA<jats:sub>A<\/jats:sub> receptor \u03b1, \u03b2, and \u03b3 subunit classes all share roughly the same degree of sequence similarity. Thus, although they are most similar to other invertebrate GABA receptors, the UNC\u201049 receptors share significant structural and pharmacological overlap with mammalian GABA<jats:sub>A<\/jats:sub> receptors.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2003) <jats:bold>138<\/jats:bold>, 883\u2013893. doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0705119\">10.1038\/sj.bjp.0705119<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0705119","type":"journal-article","created":{"date-parts":[[2003,3,17]],"date-time":"2003-03-17T18:23:15Z","timestamp":1047925395000},"page":"883-893","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Pharmacological characterization of the homomeric and heteromeric UNC\u201049 GABA receptors in <i>C. elegans<\/i>"],"prefix":"10.1111","volume":"138","author":[{"given":"Bruce A","family":"Bamber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy E","family":"Twyman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik M","family":"Jorgensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1987.sp016861"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-13-05348.1999"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15439.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-0186(99)00037-6"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.5.14.1661244"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.13.6069"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.7.2673"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-76-1-46"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0700987"},{"key":"e_1_2_7_11_1","first-page":"539","article-title":"The methylglutamate, SYM 2081, is a potent and highly selective agonist at kainate receptors","volume":"285","author":"DONEVAN S.D.","year":"1998","journal-title":"J. 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