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The temporal declining of intracellular cyclic AMP was not dependent on the cyclic AMP breakdown but associated to the efflux of cyclic nucleotide to the extracellular compartment, by an active transport since it was prevented by probenecid.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2003) <jats:bold>138<\/jats:bold>, 995\u20131003. doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0705130\">10.1038\/sj.bjp.0705130<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0705130","type":"journal-article","created":{"date-parts":[[2003,3,17]],"date-time":"2003-03-17T18:23:15Z","timestamp":1047925395000},"page":"995-1003","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Regulation of intracellular cyclic AMP in skeletal muscle cells involves the efflux of cyclic nucleotide to the extracellular compartment"],"prefix":"10.1111","volume":"138","author":[{"given":"Rosely Oliveira","family":"Godinho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valter Luiz","family":"Costa\u2010Jr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(99)00199-9"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00419-2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/frne.1999.0193"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1050-1738(02)00167-6"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.61.1.169"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.137.12.5519"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(96)13102-5"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1996.76.6.3910"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/249380a0"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00514-8"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(91)90368-Z"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704069"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)51859-7"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2000.279.3.F400"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3270899"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.36.3.337"},{"key":"e_1_2_7_19_1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1042\/cs0700435","article-title":"Thermogenesis in human skeletal muscle as measured by direct microcalorimetry and muscle contractile performance during beta\u2010adrenoceptor blockade","volume":"70","author":"FAGHER B.","year":"1986","journal-title":"Clin. 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