{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T22:33:28Z","timestamp":1789598008979,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":2130,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2003,4]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>The presence and profile of purinoceptors in neurons of the hamster submandibular ganglion (SMG) have been studied using the whole\u2010cell configuration of the patch\u2010clamp technique.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Extracellular application of adenosine 5\u2032\u2010triphosphate (ATP) reversibly inhibited voltage\u2010dependent Ca<jats:sup>2+<\/jats:sup> channel (VDCC) currents (<jats:italic>I<\/jats:italic><jats:sub>Ca<\/jats:sub>) via G<jats:sub>i\/o<\/jats:sub>\u2010protein in a voltage\u2010dependent manner.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Extracellular application of uridine 5\u2032\u2010triphosphate (UTP), 2\u2010methylthioATP (2\u2010MeSATP), <jats:italic>\u03b1<\/jats:italic>,<jats:italic>\u03b2<\/jats:italic>\u2010methylene ATP (<jats:italic>\u03b1<\/jats:italic>,<jats:italic>\u03b2<\/jats:italic>\u2010MeATP) and adenosine 5\u2032\u2010diphosphate (ADP) also inhibited <jats:italic>I<\/jats:italic><jats:sub>Ca<\/jats:sub>. The rank order of potency was ATP=UTP&gt;ADP&gt;2\u2010MeSATP=<jats:italic>\u03b1<\/jats:italic>,<jats:italic>\u03b2<\/jats:italic>\u2010MeATP.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The P2 purinoceptor antagonists, suramin and pyridoxal\u20105\u2010phosphate\u20106\u2010azophenyl\u20102\u2032, 4\u2032\u2010disulfonic acid (PPADS), partially antagonized the ATP\u2010induced inhibition of <jats:italic>I<\/jats:italic><jats:sub>Ca<\/jats:sub>, while coapplication of suramin and the P1 purinoceptor antagonist, 8\u2010cyclopentyl\u20101,3\u2010dipropylxanthine (DPCPX), virtually abolished <jats:italic>I<\/jats:italic><jats:sub>Ca<\/jats:sub> inhibition. DPCPX alone partially antagonized <jats:italic>I<\/jats:italic><jats:sub>Ca<\/jats:sub> inhibition.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Suramin antagonized the UTP\u2010induced inhibition of <jats:italic>I<\/jats:italic><jats:sub>Ca<\/jats:sub>, while DPCPX had no effect.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Extracellular application of adenosine (ADO) also inhibited <jats:italic>I<\/jats:italic><jats:sub>Ca<\/jats:sub> in a voltage\u2010dependent manner via G<jats:sub>i\/o<\/jats:sub>\u2010protein activation.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Mainly N\u2010 and P\/Q\u2010type VDCCs were inhibited by both ATP and ADO via G<jats:sub>i\/o<\/jats:sub>\u2010protein <jats:italic>\u03b2\u03b3<\/jats:italic> subunits in seemingly convergence pathways.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2003) <jats:bold>138<\/jats:bold>, 1535\u20131543. doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0705174\">10.1038\/sj.bjp.0705174<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0705174","type":"journal-article","created":{"date-parts":[[2003,4,29]],"date-time":"2003-04-29T17:18:42Z","timestamp":1051636722000},"page":"1535-1543","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Extracellular ATP\u2010induced calcium channel inhibition mediated by P1\/P2Y purinoceptors in hamster submandibular ganglion neurons"],"prefix":"10.1111","volume":"138","author":[{"given":"Mitsuhiro","family":"Abe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Endoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00370241"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/340153a0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(98)01170-5"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701880"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1990.tb37657.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(97)00125-1"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/385446a0"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(96)81865-0"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.003bx.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1992.sp019162"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(98)00002-8"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"5170","DOI":"10.1523\/JNEUROSCI.18-14-05170.1998","article-title":"P2Y2 nucleotide receptors expressed heterologously in sympathetic neurons inhibit both N\u2010type Ca2+ and M\u2010type K+ currents","volume":"18","author":"FILIPPOV A.K.","year":"1998","journal-title":"J. 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