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Cellular migration and AHR were examined 24 h after the second ovalbumin (OA) challenge.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>R\u2010715 (10\u2013500 <jats:italic>\u03bc<\/jats:italic>g kg<jats:sup>\u22121<\/jats:sup>) and R\u2010954 (1\u2013100 <jats:italic>\u03bc<\/jats:italic>g kg<jats:sup>\u22121<\/jats:sup>) injected intravenously (i.v.), 5 min prior to aerosol OA challenges, decreased by approximately 50% the induced lung eosinophilia in OA\u2010sensitized mice but did not reduce AHR.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>HOE\u2010140 (1 <jats:italic>\u03bc<\/jats:italic>g kg<jats:sup>\u22121<\/jats:sup>) administered in the same manner, decreased mononuclear cell and eosinophil infiltration in the bronchoalveolar lavage fluid (BALF) of OA\u2010sensitized mice. Moreover, treatment of OA\u2010sensitized mice with HOE\u2010140 (100 <jats:italic>\u03bc<\/jats:italic>g kg<jats:sup>\u22121<\/jats:sup>) completely abolished the AHR to carbachol.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The BKB<jats:sub>1<\/jats:sub>\u2010R agonist desArg<jats:sup>9<\/jats:sup>\u2010BK (DBK; 10\u20131000 <jats:italic>\u03bc<\/jats:italic>g kg<jats:sup>\u22121<\/jats:sup>) administered intratrachealy to normal mice had no effect on the basal cell counts recovered in BALF nor on the plasma extravasation, while the BKB<jats:sub>2<\/jats:sub>\u2010R selective agonist BK (20 <jats:italic>\u03bc<\/jats:italic>g kg<jats:sup>\u22121<\/jats:sup>) stimulated mononuclear cell migration, neutrophilia and plasma extravasation in normal mouse lungs. Such effects were inhibited by HOE\u2010140 (10 <jats:italic>\u03bc<\/jats:italic>g kg<jats:sup>\u22121<\/jats:sup>).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Our results suggest that the airway inflammatory response induced by antigen challenge in mice is mediated by stimulation of both BKB<jats:sub>1<\/jats:sub>\u2010R and BKB<jats:sub>2<\/jats:sub>\u2010R.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2003) <jats:bold>138<\/jats:bold>, 1589\u20131597. doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0705207\">10.1038\/sj.bjp.0705207<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0705207","type":"journal-article","created":{"date-parts":[[2003,4,29]],"date-time":"2003-04-29T17:18:42Z","timestamp":1051636722000},"page":"1589-1597","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Implication of the bradykinin receptors in antigen\u2010induced pulmonary inflammation in mice"],"prefix":"10.1111","volume":"138","author":[{"given":"Jadranka","family":"Eric","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bichoy H","family":"Gabra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Sirois","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.4049\/jimmunol.156.1.269","article-title":"Involvement of bradykinin B1 receptors in the polymorphonuclear leukocyte accumulation induced by IL\u20101\u03b2 in vivo in the mouse","volume":"156","author":"AHLUWALIA A.","year":"1996","journal-title":"J. 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