{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T20:37:30Z","timestamp":1774125450377,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,1,30]],"date-time":"2009-01-30T00:00:00Z","timestamp":1233273600000},"content-version":"vor","delay-in-days":2009,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2003,8]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>The sensitivity of the particulate guanylate cyclase\u2013cyclic guanosine\u20103\u2032,5\u2032\u2010monophosphate (cGMP) system to atrial (ANP) and C\u2010type (CNP) natriuretic peptides was investigated in aortae and mesenteric small arteries from wild\u2010type (WT) and endothelial nitric oxide synthase (eNOS) knockout (KO) mice.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>ANP and CNP produced concentration\u2010dependent relaxations of mouse aorta that were significantly attenuated by the natriuretic peptide receptor (NPR)\u2010A\/B antagonist HS\u2010142\u20101 (10<jats:sup>\u22125<\/jats:sup> <jats:sc>M<\/jats:sc>). Both ANP and CNP were more potent in aortae from eNOS KO mice compared to WT.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The potency of ANP and CNP in aortae from WT animals was increased in the presence of the NOS inhibitor, <jats:italic>N<\/jats:italic><jats:sup>G<\/jats:sup>\u2010nitro\u2010<jats:sc>L<\/jats:sc>\u2010arginine (3 \u00d7 10<jats:sup>\u22124<\/jats:sup> <jats:sc>M<\/jats:sc>) and the soluble guanylate cyclase inhibitor 1H\u2010[1,2,4]oxadiazolol[4,3,a]quinoxalin\u20101\u2010one (5 \u00d7 10<jats:sup>\u22126<\/jats:sup> <jats:sc>M<\/jats:sc>).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In contrast, the potency of ANP and CNP in aortae from eNOS KO animals was reduced following pretreatment of tissues with supramaximal concentrations of the NO\u2010donor, glyceryl trinitrate (3 \u00d7 10<jats:sup>\u22125<\/jats:sup> <jats:sc>M<\/jats:sc>, 30 min) or ANP (10<jats:sup>\u22127<\/jats:sup> <jats:sc>M<\/jats:sc>, 30 min).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Responses to acetylcholine in aortae from WT mice (dependent on the release of endothelium\u2010derived NO) were significantly reduced following pretreatment of tissues with GTN (3 \u00d7 10<jats:sup>\u22125<\/jats:sup> <jats:sc>M<\/jats:sc>, 30 min) and ANP (10<jats:sup>\u22127<\/jats:sup> <jats:sc>M<\/jats:sc>, 30 min).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>CNP and the NO\u2010donor, spermine\u2010NONOate caused concentration\u2010dependent relaxations of mesenteric small arteries from WT animals that were significantly increased in eNOS KO mice compared to WT. ANP was unable to significantly relax mesenteric arteries from WT or eNOS KO animals.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In conclusion, both NPR\u2010A\u2010 and NPR\u2010B\u2010linked pGC pathways are modulated by NO\u2013cGMP in murine aorta and mesenteric small arteries and crossdesensitisation occurs between NPR subtypes. The biological activity of endothelium\u2010derived NO is also influenced by the ambient concentration of NO and natriuretic peptides. Such an autoregulatory pathway may represent an important physiological homeostatic mechanism and link the paracrine activity of NO and CNP with the endocrine functions of ANP and BNP in the regulation of vascular tone and blood pressure.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2003) <jats:bold>139<\/jats:bold>, 1289\u20131296. doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0705365\">10.1038\/sj.bjp.0705365<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0705365","type":"journal-article","created":{"date-parts":[[2003,7,30]],"date-time":"2003-07-30T15:17:24Z","timestamp":1059578244000},"page":"1289-1296","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Vascular natriuretic peptide receptor\u2010linked particulate guanylate cyclases are modulated by nitric oxide\u2013cyclic GMP signalling"],"prefix":"10.1111","volume":"139","author":[{"given":"Melanie","family":"Madhani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramona S","family":"Scotland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond J","family":"MacAllister","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian J","family":"Hobbs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199807000-00009"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/338078a0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.9.4668"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2000.0752029.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(01)00331-5"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(97)01137-1"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/377239a0"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702874"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.280.3.H1151"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(01)00327-3"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807303390507"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1996.257"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2823385"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1998.275.5.H1826"},{"key":"e_1_2_7_16_1","first-page":"109","article-title":"Nitric oxide: physiology, pathophysiology, and pharmacology","volume":"43","author":"MONCADA S.","year":"1991","journal-title":"Pharmacol. 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