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The neuroprotective effect of LF 16\u20100687 Ms, a B<jats:sub>2<\/jats:sub> receptor antagonist, has been described when given prior to induction of transient focal cerebral ischemia in rat, but there are no data regarding the consequence of a treatment when given after injury. Therefore, in a murine model of transient middle cerebral artery occlusion (MCAO), we evaluated the effect of LF 16\u20100687 Ms given prior to and\/or after the onset of ischemia on neurological deficit, infarct volume and inflammatory responses including cerebral edema, blood\u2013brain barrier (BBB) disruption and neutrophil accumulation.<\/jats:p>\n<\/jats:list-item>\n<jats:list-item>\n<jats:p>LF 16\u20100687 Ms (1, 2 and 4 mg kg<jats:sup>\u22121<\/jats:sup>) administered 0.5 h before and, 1.25 and 6 h after MCAO, decreased the infarct volume by a maximum of 33% and significantly improved the neurological recovery.<\/jats:p>\n<\/jats:list-item>\n<jats:list-item>\n<jats:p>When given at 0.25 and 6.25 h after MCAO, LF 16\u20100687 Ms (1.5, 3 and 6 mg kg<jats:sup>\u22121<\/jats:sup>) decreased the infarct volume by a maximum of 25% and improved the neurological score.<\/jats:p>\n<\/jats:list-item>\n<jats:list-item>\n<jats:p>Post\u2010treatment with LF 16\u20100687 Ms (1.5 mg kg<jats:sup>\u22121<\/jats:sup>) significantly decreased brain edema (\u221228%), BBB disruption (\u221260%) and neutrophil accumulation (\u221265%) induced by ischemia. Physiological parameters were not modified by LF 16\u20100687 Ms.<\/jats:p>\n<\/jats:list-item>\n<jats:list-item>\n<jats:p>These data emphasize the role of bradykinin B<jats:sub>2<\/jats:sub> receptor in the development of infarct lesion, neurological deficit and inflammatory responses resulting from transient focal cerebral ischemia. Therefore, B<jats:sub>2<\/jats:sub> receptor antagonist might represent a new therapeutic approach in the pharmacological treatment of stroke.<\/jats:p>\n<\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2003) <jats:bold>139<\/jats:bold>, 1539\u20131547. doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0705385\">10.1038\/sj.bjp.0705385<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0705385","type":"journal-article","created":{"date-parts":[[2003,8,15]],"date-time":"2003-08-15T15:44:23Z","timestamp":1060962263000},"page":"1539-1547","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["LF 16\u20100687 Ms, a bradykinin B<sub>2<\/sub> receptor antagonist, reduces ischemic brain injury in a murine model of transient focal cerebral ischemia"],"prefix":"10.1111","volume":"139","author":[{"given":"Li","family":"Ding\u2010Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Margaill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Palmier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Pruneau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Plotkine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Marchand\u2010Verrecchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490290309"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.17.6.1304"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2001.013"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0162-3109(96)00067-7"},{"key":"e_1_2_6_6_1","first-page":"1","article-title":"Bioregulation of kinins: kallikreins, kininogens, and kininases","volume":"44","author":"BHOOLA K.D.","year":"1992","journal-title":"Pharmacol. 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