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Hypotension was only reduced by the LTC<jats:sub>4<\/jats:sub>antagonist. The COX\u20101 inhibitor flunixin (1 mg kg<jats:sup>\u22121<\/jats:sup>i.v.) did not effect improvement in the markers of tissue injury.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>Histological examination of rat I\/R injury showed that all of the drugs offered some protection to the mucosal layer damage compared to no drug treatment. Given i.v., the sPLA<jats:sub>2<\/jats:sub>inhibitor was more effective than either the COX\u20101 or COX\u20102 inhibitors in preventing rat I\/R injury.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>These results indicate that a potent new inhibitor of sPLA<jats:sub>2<\/jats:sub>(group IIa) protects the rat small intestine from I\/R injury after oral or intravenous administration. COX\u20102 and LTC<jats:sub>4<\/jats:sub>inhibitors also showed some beneficial effects against intestinal I\/R injury. Our study suggests that sPLA<jats:sub>2<\/jats:sub>(Group IIa) may have a pathogenic role in intestinal I\/R in rats.<\/jats:p><\/jats:list-item><\/jats:list><\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic>(2003)<jats:bold>140<\/jats:bold>, 71\u201380. doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0705402\">10.1038\/sj.bjp.0705402<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0705402","type":"journal-article","created":{"date-parts":[[2003,9,10]],"date-time":"2003-09-10T15:50:23Z","timestamp":1063209023000},"page":"71-80","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA<sub>2<\/sub>, COX\u20101 and COX\u20102 selective inhibitors, and an LTC<sub>4<\/sub>receptor antagonist"],"prefix":"10.1111","volume":"140","author":[{"given":"Thiruma V","family":"Arumugam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Arnold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavinia M","family":"Proctor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Newman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C","family":"Reid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl A","family":"Hansford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P","family":"Fairlie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian A","family":"Shiels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1681.2002.03766.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.2002.6369"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.39.1.175"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1381.1999.99321.x"},{"key":"e_1_2_7_6_1","first-page":"184","article-title":"Reperfusion mucosal damage after complete intestinal ischemia in the dog: the effects of antioxidant and phospholipase A2 inhibitor therapy","volume":"113","author":"BOROS M.","year":"1993","journal-title":"Surgery"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-199509000-00003"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2001.62.1755"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(99)00681-0"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.6.mar6"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2000.tb05335.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199012000-00007"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(87)90512-0"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.00722.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2760(98)00098-8"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1970.01340280030009"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0967-2109(96)83778-1"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200038030-00003"},{"key":"e_1_2_7_19_1","first-page":"H2572","article-title":"Ischemic\u2013reperfused isolated working mouse hearts: membrane damage and type IIA phospholipase A2","volume":"280","author":"DE WINDT L.J.","year":"2001","journal-title":"Am. 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