{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T05:40:02Z","timestamp":1792129202602,"version":"4.4.0"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,2,2]],"date-time":"2009-02-02T00:00:00Z","timestamp":1233532800000},"content-version":"vor","delay-in-days":1951,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2003,10]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>The administration of <jats:italic>\u03ba<\/jats:italic>\u2010opioid receptor antagonists, nor\u2010binaltorphimine (norBNI) and 5\u2032\u2010guanidinonaltrindole (GNTI) enhanced allodynia in rats and mice after sciatic nerve ligation. In order to understand the mechanism underlying this effect, we examined the possible involvement of the endogenous ligand of <jats:italic>\u03ba<\/jats:italic>\u2010opioid receptor dynorphin.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The experiments were carried out on male Wistar rats and on Albino\u2010Swiss mice. The rats had been implanted with a catheter 7 days earlier in the subarachnoid space of the spinal cord. Intrathecal (i.t.) administrations in mice were made by lumbar puncture. The animals were i.t. injected with norBNI, GNTI (<jats:italic>\u03ba<\/jats:italic>\u2010opioid receptor antagonists), dynorphin A<jats:sub>1\u201317<\/jats:sub> antiserum (DYN A\/S), ketamine (NMDA receptor antagonist) and their combinations. The nociceptive sensitivity was assessed using the mechanical (von Frey) and therma allodynia tests on days 2\u20134 and 8\u201310 after the sciatic nerve ligation.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Both antagonists, norBNI and GNTI, significantly enhanced mechanical and therma allodynia in rats and mice with neuropathic pain. The potentiation of allodynia after the administration of norBNI or GNTI was inhibited by earlier administration of DYN A\/S or by ketamine.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Our results suggest that allodynia is mediated through nonopioid effect of the endogenous opioid peptide, dynorphin. The nonopioid action is potentiated by the blockade of <jats:italic>\u03ba<\/jats:italic>\u2010opioid receptors, and corresponding to the elevation of prodynorphin mRNA level in neuropathic pain. Furthermore, the potentiation of allodynia after the administration of the above drugs appears to be mediated through the activation of NMDA receptors directly by dynorphin.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2003) <jats:bold>140<\/jats:bold>, 538\u2013546. doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0705427\">10.1038\/sj.bjp.0705427<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0705427","type":"journal-article","created":{"date-parts":[[2003,10,1]],"date-time":"2003-10-01T17:39:04Z","timestamp":1065029944000},"page":"538-546","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Antagonists of the <i>\u03ba<\/i>\u2010opioid receptor enhance allodynia in rats and mice after sciatic nerve ligation"],"prefix":"10.1111","volume":"140","author":[{"given":"I","family":"Obara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Mika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M K \u2010H","family":"Sch\u00e4fer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Przewlocka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,2,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(87)52071-7"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90209-6"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01393-1"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(87)90397-9"},{"key":"e_1_2_12_6_1","first-page":"1269","article-title":"Kappa opioid antagonist effects of systemically administered nor\u2010binaltorphimine in a thermal antinociception assay in rhesus monkeys","volume":"267","author":"BUTELMAN E.R.","year":"1993","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)91579-4"},{"key":"e_1_2_12_8_1","doi-asserted-by":"crossref","first-page":"4602","DOI":"10.1523\/JNEUROSCI.15-06-04602.1995","article-title":"The mechanism of action for the block of NMDA receptor channels by the opioid peptide dynorphin","volume":"15","author":"CHEN L.","year":"1995","journal-title":"J. Neurosci."},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(94)90023-X"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4179(85)90082-4"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)91231-O"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270111"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1984.tb10074.x"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002210050280"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(97)00070-8"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(91)90136-L"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(80)90515-4"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90141-8"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)02624-5"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00208-9"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(90)90187-A"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(97)00046-8"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(95)12034-2"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(00)00243-8"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(89)90149-0"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(01)00814-7"},{"key":"e_1_2_12_27_1","first-page":"784","article-title":"Opioid antagonists and antisera to endogenous opioids increase the nociceptive response to formalin: demonstration of an opioid kappa and delta inhibitory tone","volume":"277","author":"OSSIPOV M.H.","year":"1996","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(98)00956-X"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(02)00246-X"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(88)90016-2"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4179(83)90019-7"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(83)90586-6"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.2.622"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(94)91046-4"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.13-03-01258.1993"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)01327-9"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200212200-00015"},{"key":"e_1_2_12_38_1","first-page":"833","article-title":"Dynorphin A and related peptides administered intrathecally in the rat: a search for putative kappa opiate receptor activity","volume":"238","author":"STEVENS C.W.","year":"1986","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm0000665"},{"key":"e_1_2_12_40_1","first-page":"760","article-title":"High\u2010affinity interaction of (des\u2010Tyrosyl)dynorphin A(2\u201317) with NMDA receptors","volume":"291","author":"TANG Q.","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(96)03225-3"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-05-01779.2001"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(97)03337-X"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(76)90029-9"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(97)13475-9"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.bjp.0705427","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.bjp.0705427","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/sj.bjp.0705427","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T20:31:43Z","timestamp":1697229103000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1038\/sj.bjp.0705427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,10]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,10]]}},"alternative-id":["10.1038\/sj.bjp.0705427"],"URL":"https:\/\/doi.org\/10.1038\/sj.bjp.0705427","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,10]]},"assertion":[{"value":"2009-02-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}