{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T15:31:40Z","timestamp":1759073500764},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,2,2]],"date-time":"2009-02-02T00:00:00Z","timestamp":1233532800000},"content-version":"vor","delay-in-days":1951,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2003,10]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Rat stomach ECL cells release histamine in response to gastrin. Submucosal microinfusion of endothelin or adrenaline, known to cause vasoconstriction and gastric lesions, mobilized striking amounts of histamine. While the histamine response to gastrin is sustainable for hours, that to endothelin and adrenaline was characteristically short\u2010lasting (1\u20132 h).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The aims of this study were to identify the cellular source of histamine mobilized by endothelin and adrenaline, and examine the differences between the histamine\u2010mobilizing effects of gastrin, and of endothelin and adrenaline.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Endothelin, adrenaline or gastrin were administered by submucosal microinfusion. Gastric histamine mobilization was monitored by microdialysis.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Local pretreatment with the H<jats:sub>1<\/jats:sub>\u2010receptor antagonist mepyramine and the H<jats:sub>2<\/jats:sub>\u2010receptor antagonist ranitidine did not prevent endothelin\u2010 or adrenaline\u2010induced mucosal damage. Submucosal microinfusion of histamine did not cause damage. Acid blockade by ranitidine or omeprazole prevented the damage, suggesting that acid back diffusion contributes.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Gastrin raised histidine decarboxylase (HDC) activity close to the probe, without affecting the histamine concentration. Endothelin and adrenaline lowered histamine by 50\u201370%, without activating HDC. Histamine mobilization declined upon repeated administration. Endothelin reduced the number of histamine\u2010immunoreactive ECL cells locally, and reduced the number of secretory vesicles. Thus, unlike gastrin, endothelin (and adrenaline) is capable of exhausting ECL\u2010cell histamine.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Microinfusion of <jats:italic>\u03b1<\/jats:italic>\u2010fluoromethylhistidine (known to deplete ECL cells but not mast cells of histamine) reduced the histamine\u2010mobilizing effect of endothelin by 80%, while 1\u2010week pretreatment with omeprazole enhanced it, supporting the involvement of ECL cells.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Somatostatin or the prostanoid misoprostol inhibited gastrin\u2010, but not endothelin\u2010stimulated histamine release, suggesting that endothelin and gastrin mobilize histamine <jats:italic>via<\/jats:italic> different mechanisms.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>While gastrin effectively mobilized histamine from ECL cells in primary culture, endothelin had no effect, and adrenaline, a modest effect. Hence, the striking effects of endothelin and adrenaline on ECL cells <jats:italic>in situ<\/jats:italic> are probably indirect, possibly a consequence of ischemia.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2003) <jats:bold>140<\/jats:bold>, 707\u2013717. doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0705473\">10.1038\/sj.bjp.0705473<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0705473","type":"journal-article","created":{"date-parts":[[2003,10,8]],"date-time":"2003-10-08T18:40:45Z","timestamp":1065638445000},"page":"707-717","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Submucosal microinfusion of endothelin and adrenaline mobilizes ECL\u2010cell histamine in rat stomach, and causes mucosal damage: a microdialysis study"],"prefix":"10.1111","volume":"140","author":[{"given":"M","family":"Bernsand","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Ericsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Bj\u00f6rkqvist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C \u2010M","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"H\u00e5kanson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Norl\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529609031622"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00381874"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000200272"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90056-6"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0773.2003.930201.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00492340"},{"key":"e_1_2_7_8_1","first-page":"1171","volume-title":"Physiology of the Gastrointestinal Tract","author":"H\u00c5KANSON R.","year":"1994"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90693-2"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(74)90267-X"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-0115(99)00096-8"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000139523"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/274906a0"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704037"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(86)90938-8"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-0115(97)01018-5"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1095-6433(00)00331-7"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.00663.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701953"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-0115(00)00217-2"},{"key":"e_1_2_7_21_1","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/0016-5085(94)90758-7","article-title":"Role of endothelin\u20101 in hemorrhagic shock\u2010induced gastric mucosal injury in rats","volume":"130","author":"MICHIDA T.","year":"1994","journal-title":"Gastroenterology"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704419"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703347"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/36.3.3343510"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01966641"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365528708991918"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000199269"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.1973.12096677"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1991.tb12138.x"},{"key":"e_1_2_7_30_1","first-page":"G661","article-title":"Endothelin has potent ulcerogenic and vasoconstrictor actions in the stomach","volume":"256","author":"WALLACE J.L.","year":"1989","journal-title":"Am. J. Physiol."},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005556520813"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1993.tb13763.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1988.tb11733.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004419900075"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.bjp.0705473","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.bjp.0705473","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/sj.bjp.0705473","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T05:11:28Z","timestamp":1697173888000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1038\/sj.bjp.0705473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,10]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,10]]}},"alternative-id":["10.1038\/sj.bjp.0705473"],"URL":"https:\/\/doi.org\/10.1038\/sj.bjp.0705473","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,10]]},"assertion":[{"value":"2009-02-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}