{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T06:07:23Z","timestamp":1762927643454},"reference-count":57,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,2,2]],"date-time":"2009-02-02T00:00:00Z","timestamp":1233532800000},"content-version":"vor","delay-in-days":1920,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>The activation of tachykinin NK receptors by neuropeptides may induce the recruitment of eosinophils <jats:italic>in vivo<\/jats:italic>. The aim of the present study was to investigate the effects and underlying mechanism(s) of the action of tachykinin receptor antagonists on eosinophil recruitment in a model of allergic pleurisy in mice.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Pretreatment of immunized mice with capsaicin partially prevented the recruitment of eosinophils after antigen challenge, suggesting the potential contribution of sensory nerves for the recruitment of eosinophils<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Local (10\u201350 nmol per pleural cavity) or systemic (100\u2013300 nmol per animal) pretreatment with the tachykinin NK<jats:sub>1<\/jats:sub> receptor antagonist SR140333 prevented the recruitment of eosinophils induced by antigen challenge of immunized mice. Neither tachykinin NK<jats:sub>2<\/jats:sub> nor NK<jats:sub>3<\/jats:sub> receptor antagonists suppressed eosinophil recruitment.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Pretreatment with SR140333 failed to prevent the antigen\u2010induced increase of interleukin\u20105 concentrations in the pleural cavity. Similarly, SR140333 failed to affect the bone marrow eosinophilia observed at 48 h after antigen challenge of immunized mice.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>SR140333 induced a significant increase in the concentrations of antigen\u2010induced eotaxin at 6 h after challenge.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Antigen challenge of immunized mice induced a significant increase of Leucotriene B<jats:sub>4<\/jats:sub> (LTB<jats:sub>4<\/jats:sub>) concentrations at 6 h after challenge. Pretreatment with SR140333 prevented the antigen\u2010induced increase of LTB<jats:sub>4<\/jats:sub> concentrations.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Our data suggest an important role for NK<jats:sub>1<\/jats:sub> receptor activation with consequent LTB<jats:sub>4<\/jats:sub> release and eosinophil recruitment in a model of allergic pleurisy in the mouse. Tachykinins appear to be released mainly from peripheral endings of capsaicin\u2010sensitive sensory neurons and may act on mast cells to facilitate antigen\u2010driven release of LTB<jats:sub>4<\/jats:sub>.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2003) <jats:bold>140<\/jats:bold>, 847\u2013854. doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0705515\">10.1038\/sj.bjp.0705515<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0705515","type":"journal-article","created":{"date-parts":[[2003,10,29]],"date-time":"2003-10-29T21:07:59Z","timestamp":1067461679000},"page":"847-854","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Mechanisms underlying the inhibitory effects of tachykinin receptor antagonists on eosinophil recruitment in an allergic pleurisy model in mice"],"prefix":"10.1111","volume":"140","author":[{"given":"Ana Let\u00edcia","family":"Alessandri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Pinho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle G","family":"Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Salete de A","family":"Castro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro M","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,2]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"L263","article-title":"NK1 receptors mediate leukocyte adhesion in neurogenic inflammation in rat trachea","volume":"268","author":"BALUK P.","year":"1995","journal-title":"Am. 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