{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T21:04:50Z","timestamp":1769202290453,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2009,2,2]],"date-time":"2009-02-02T00:00:00Z","timestamp":1233532800000},"content-version":"vor","delay-in-days":1890,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Chronic cellular inflammation and airway wall remodelling with subepithelial fibrosis and airway smooth muscle (ASM) cell hyperplasia are features of chronic asthma. Jun N\u2010terminal kinase (JNK) may be implicated in these processes by regulating the transcriptional activity of activator protein (AP)\u20101.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>We examined the effects of an inhibitor of JNK, SP600125 (anthra [1,9\u2010cd] pyrazole\u20106 (2 H)\u2010one), in a model of chronic allergic inflammation in the rat.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Rats sensitised to ovalbumin (OA) were exposed to OA\u2010aerosol every third day on six occasions and were treated with SP600125 (30 mg kg<jats:sup>\u22121<\/jats:sup> b.i.d; 360 mg in total) for 12 days, starting after the second through to the sixth OA exposure. We measured eosinophilic and T\u2010cell inflammation in the airways, proliferation of ASM cells and epithelial cells by incorporation of bromodeoxyuridine (BrdU), and bronchial responsiveness to acetylcholine.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>SP600125 significantly reduced the number of eosinophils (<jats:italic>P<\/jats:italic>&lt;0.05) and lymphocytes (<jats:italic>P<\/jats:italic>&lt;0.05) in bronchoalveolar lavage fluid, suppressed eosinophilic (<jats:italic>P<\/jats:italic>&lt;0.05) and CD<jats:sub>2<\/jats:sub><jats:sup>+<\/jats:sup> T\u2010cell (<jats:italic>P<\/jats:italic>&lt;0.05) infiltration within the bronchial submucosa, and the increased DNA incorporation in ASM (<jats:italic>P<\/jats:italic>&lt;0.05) and epithelial cell incorporation (<jats:italic>P<\/jats:italic>&lt;0.05).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>SP600125 did not alter bronchial hyper\u2010responsiveness observed after chronic allergen exposure.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Pathways regulated by JNK positively regulate ASM cell proliferation and allergic cellular inflammation following chronic allergen exposure.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2003) <jats:bold>140<\/jats:bold>, 1373\u20131380. doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0705569\">10.1038\/sj.bjp.0705569<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0705569","type":"journal-article","created":{"date-parts":[[2003,12,10]],"date-time":"2003-12-10T20:40:28Z","timestamp":1071088828000},"page":"1373-1380","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Allergen\u2010induced inflammation and airway epithelial and smooth muscle cell proliferation: role of Jun N\u2010terminal kinase"],"prefix":"10.1111","volume":"140","author":[{"given":"Paul R","family":"Eynott","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Puneeta","family":"Nath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sum\u2010Yee","family":"Leung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian M","family":"Adcock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brydon L","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K Fan","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.101.4.916"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/142.6_Pt_1.1407"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.251194298"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199010113231505"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(91)90160-P"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.54.9.825"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.41.28978"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb\/7.2.128"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(05)80058-3"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/142.4.863"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.24.2.176"},{"key":"e_1_2_6_13_1","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1164\/ajrccm\/148.3.720","article-title":"Cellular hypertrophy and hyperplasia of airway smooth muscle underlying bronchial asthma","volume":"148","author":"EBINA M.","year":"1993","journal-title":"Am. 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