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These effects of AC\u20105216 were antagonized by PK11195, an MBR antagonist. In the forced swimming test in rats, AC\u20105216 (3\u201330 mg kg<jats:sup>\u22121<\/jats:sup>, p.o.) reduced the immobility time, and this effect was blocked by PK11195.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>AC\u20105216 had no myorelaxant effects, did not affect the memory or prolong hexobarbitone\u2010induced sleep in mice, even at doses as high as 1000 mg kg<jats:sup>\u22121<\/jats:sup>, p.o. Although it did slightly prolong the ethanol\u2010induced sleep time at 1000 mg kg<jats:sup>\u22121<\/jats:sup>, AC\u20105216 (1\u2013100 mg kg<jats:sup>\u22121<\/jats:sup>, p.o.) produced no distinct change in the rat electroencephalogram.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These results indicate that AC\u20105216 produces anti\u2010anxiety and antidepressant\u2010like effects that are mediated by MBR, but does not cause the side effects normally associated with conventional benzodiazepines. Hence, AC\u20105216 shows potential for the treatment of stress\u2010related disorders including anxiety and depression.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2004) <jats:bold>142<\/jats:bold>, 1059\u20131072. doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0705681\">10.1038\/sj.bjp.0705681<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0705681","type":"journal-article","created":{"date-parts":[[2004,7,29]],"date-time":"2004-07-29T20:52:18Z","timestamp":1091134338000},"page":"1059-1072","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":115,"title":["Antianxiety and antidepressant\u2010like effects of AC\u20105216, a novel mitochondrial benzodiazepine receptor ligand"],"prefix":"10.1111","volume":"142","author":[{"given":"Atsuko","family":"Kita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Kohayakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Kinoshita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Ochi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Nakamichi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Kurumiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Furukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Oka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.04-02-00593.1984"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)36131-8"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1014425"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1986.tb12965.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006456715525"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)90761-J"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-0186(01)00118-8"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(00)00588-8"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/frne.1999.0188"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(89)90033-6"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(87)90033-5"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.301.3.1067"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(80)90012-6"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(88)90005-6"},{"key":"e_1_2_7_16_1","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1523\/JNEUROSCI.01-02-00218.1981","article-title":"[3H]Diazepam binding in mammalian central nervous system: a pharmacological characterization","volume":"1","author":"GALLAGER D.W.","year":"1981","journal-title":"J. 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