{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:03:09Z","timestamp":1773421389707,"version":"3.50.1"},"reference-count":57,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":1734,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Studies in rats suggest that PACAP modulates gastric acid secretion through the release of both histamine and somatostatin.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>We characterized the effects of exogenous PACAP on gastric acid secretion in urethane\u2010anesthetized mice implanted with a gastric cannula and in conscious 2\u2010h pylorus ligated mice, and determined the involvement of somatostatin and somatostatin receptor type 2 (SSTR2) by using somatostatin immunoneutralization, the SSTR2 antagonist, PRL\u20102903, and SSTR2 knockout mice.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Urethane\u2010anesthetized wild\u2010type mice had low basal acid secretion (0.10\u00b10.01 <jats:italic>\u03bc<\/jats:italic>mol (10 min)<jats:sup>\u22121<\/jats:sup>) compared with SSTR2 knockout mice (0.93\u00b10.07 <jats:italic>\u03bc<\/jats:italic>mol (10 min)<jats:sup>\u22121<\/jats:sup>). Somatostatin antibody and PRL\u20102903 increased basal secretion in wild\u2010type mice but not in SSTR2 knockout animals.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In wild\u2010type urethane\u2010anesthetized mice, PACAP\u201038 (3\u2013270 <jats:italic>\u03bc<\/jats:italic>g kg<jats:sup>\u22121<\/jats:sup> h<jats:sup>\u22121<\/jats:sup>) did not affect the low basal acid secretion, but inhibited the acid response to pentagastrin, histamine, and bethanechol.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In wild\u2010type urethane\u2010anesthetized mice pretreated with somatostatin antibody or PRL\u20102903 and in SSTR2 knockout mice, peripheral infusion of PACAP\u201038 or somatostatin\u201014 did not inhibit the increased basal gastric acid secretion.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In conscious wild\u2010type mice, but not in SSTR2 knockout mice, PACAP\u201038 inhibited gastric acid secretion induced by 2\u2010h pylorus ligation. The antisecretory effect of PACAP\u201038 was prevented by immunoneutralization of somatostatin.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These results indicate that, in mice, peripheral PACAP inhibits gastric acid secretion through the release of somatostatin and the activation of SSTR2 receptors. There is no evidence for stimulatory effects of PACAP on acid secretion in mice.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2004) <jats:bold>142<\/jats:bold>, 67\u201378. doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0705739\">10.1038\/sj.bjp.0705739<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0705739","type":"journal-article","created":{"date-parts":[[2004,5,6]],"date-time":"2004-05-06T18:18:08Z","timestamp":1083867488000},"page":"67-78","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Peripheral PACAP inhibits gastric acid secretion through somatostatin release in mice"],"prefix":"10.1111","volume":"142","author":[{"given":"Laura","family":"Piqueras","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvette","family":"Tach\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10466"},{"key":"e_1_2_7_3_1","first-page":"245","article-title":"Somatostatin inhibition of acid and histamine release by activation of somatostatin receptor subtype 2 receptors in rats","volume":"281","author":"AURANG K","year":"1997","journal-title":"J. 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