{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:49:24Z","timestamp":1791910164432,"version":"4.3.4"},"reference-count":64,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2009,1,30]],"date-time":"2009-01-30T00:00:00Z","timestamp":1233273600000},"content-version":"vor","delay-in-days":1765,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>The exquisite specific excitatory and desensitising actions of capsaicin on a subpopulation of primary sensory neurons have been instrumental in identifying the roles of these neurons in nociception, reflex responses and neurogenic inflammation.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Structure activity studies with capsaicin\u2010like molecules have suggested that a \u2018receptor\u2019 should mediate the effects of capsaicin on sensory neurons. The cloning of the vanilloid receptor\u20101 (VR1) has confirmed this hypothesis.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>VR1 (TRPV1) belongs to the transient receptor potential (TRP) family of channels, and its activation by various xenobiotics, noxious temperature, extracellular low pH and high concentration of certain lipid derivatives results in cation influx and sensory nerve terminal excitation.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>TRPV1 may dimerise or form tetramers or heteromers with PLC\u2010<jats:italic>\u03b3<\/jats:italic> and TrkA or even with other TRPs. TRPV1 is markedly upregulated and\/or \u2018sensitised\u2019 under inflammatory conditions <jats:italic>via<\/jats:italic> protein kinase C\u2010<jats:italic>\u025b<\/jats:italic>\u2010, cAMP\u2010dependent PK\u2010 and PLC\u2010<jats:italic>\u03b3<\/jats:italic>\u2010dependent pathways or by exposure to dietary agents as ethanol.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>TRPV1 is expressed on sensory neurons distributed in all the regions of the gastrointestinal tract in myenteric ganglia, muscle layer and mucosa. There is evidence of TRPV1 expression also in epithelial cells of the gastrointestinal tract.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>High expression of TRPV1 has been detected in several inflammatory diseases of the colon and ileum, whereas neuropeptides released upon sensory nerve stimulation triggered by TRPV1 activation seem to play a role in intestinal motility disorders.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>TRPV1 antagonists, which will soon be available for clinical testing, may undergo scrutiny for the treatment of inflammatory diseases of the gut.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2004) <jats:bold>141<\/jats:bold>, 1313\u20131320. doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0705768\">10.1038\/sj.bjp.0705768<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0705768","type":"journal-article","created":{"date-parts":[[2004,4,20]],"date-time":"2004-04-20T20:38:47Z","timestamp":1082493527000},"page":"1313-1320","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":158,"title":["Activation and sensitisation of the vanilloid receptor: role in gastrointestinal inflammation and function"],"prefix":"10.1111","volume":"141","author":[{"given":"Pierangelo","family":"Geppetti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Trevisani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,30]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"179","article-title":"Effect of red chillies on small bowel and colonic transit and rectal sensitivity in men with irritable bowel syndrome","volume":"21","author":"AGARWAL M.K.","year":"2002","journal-title":"Indian J. Gastroenterol."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.5.2002079"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(94)90149-X"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00802-4"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.231243698"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn902"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.043422"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/39807"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/35082088"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02196"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1985.tb05077.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/35012076"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00406.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703110"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2001.27959"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(94)00097-X"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-0115(92)90516-W"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(91)90218-D"},{"key":"e_1_2_9_20_1","volume-title":"Neurogenic Inflammation","author":"GEPPETTI P.","year":"1996"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410280213"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(02)01999-5"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.65.092101.142505"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(03)02114-9"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(00)00353-5"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4892(01)00100-X"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.122196999"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.11.6155"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2002.6393"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-117-3-234"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1033.2001.02500.x"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00908-X"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(03)00461-1"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910308200513"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(00)00205-7"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm030089u"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature719"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(97)01275-2"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.7.3655"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.52.5.755"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(02)00448-3"},{"key":"e_1_2_9_42_1","doi-asserted-by":"crossref","unstructured":"OLESEN J. DIENER H.C. HUSSTEDT I.W. GOADSBY P.J. HALL D. MEIER U. POLLENTIER S. LESKO L.M.&BIBN 4096 BS CLINICAL PROOF OF CONCEPT STUDY GROUP. (2004).Calcitonin gene\u2010related peptide receptor antagonist BIBN 4096 BS for the acute treatment of migraine.N. Engl. J. Med. 350 1073\u20131075.","DOI":"10.1056\/NEJMoa030505"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(00)01466-8"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00652-9"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.046268"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/35050121"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1083646"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-3-4"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb781"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07451.x"},{"key":"e_1_2_9_51_1","first-page":"161","article-title":"Effect of cold pressor test and a high\u2010chilli diet on rectosigmoid motility in irritable bowel syndrome","volume":"19","author":"SHAH S.K.","year":"2000","journal-title":"Indian J. Gastroenterol."},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.152002699"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2002.88.1.544"},{"key":"e_1_2_9_54_1","first-page":"159","article-title":"Vanilloid (Capsaicin) receptors and mechanisms","volume":"51","author":"SZALLASI A.","year":"1999","journal-title":"Pharmacol. Rev."},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00757-2"},{"key":"e_1_2_9_56_1","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1523\/JNEUROSCI.21-04-01104.2001","article-title":"Anandamide excites central terminals of dorsal root ganglion neurons via vanilloid receptor\u20101 (VR\u20101) activation","volume":"21","author":"TOGNETTO M.","year":"2000","journal-title":"J. Neurosci."},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80564-4"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703040"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn0602-852"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.00813.x"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.042010"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10801"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01807"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04503-7"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/22761"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.bjp.0705768","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.bjp.0705768","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/sj.bjp.0705768","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T16:03:36Z","timestamp":1697213016000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1038\/sj.bjp.0705768"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4]]},"references-count":64,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2004,4]]}},"alternative-id":["10.1038\/sj.bjp.0705768"],"URL":"https:\/\/doi.org\/10.1038\/sj.bjp.0705768","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,4]]},"assertion":[{"value":"2009-01-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}