{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T12:57:13Z","timestamp":1773665833168,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":1703,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Ingestion of a poisonous mushroom <jats:italic>Clitocybe acromelalga<\/jats:italic> is known to cause severe tactile pain (allodynia) in the extremities for a month and acromelic acid (ACRO), a kainate analogue isolated from the mushroom, produces selective damage of interneurons of the rat lower spinal cord when injected either systemically or intrathecally. Since ACRO has two isomers, ACRO\u2010A and ACRO\u2010B, here we examined their acute and late effects on induction of allodynia.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Intrathecal administration of ACRO\u2010A and ACRO\u2010B provoked marked allodynia by the first stimulus 5 min after injection, which lasted over the 50\u2010min experimental period. Dose\u2010dependency of the acute effect of ACRO\u2010A on induction of allodynia showed a bell\u2010shaped pattern from 50 ag kg<jats:sup>\u22121<\/jats:sup> to 0.5 pg kg<jats:sup>\u22121<\/jats:sup> and the maximum effect was observed at 50 fg kg<jats:sup>\u22121<\/jats:sup>. On the other hand, ACRO\u2010B induced allodynia in a dose\u2010dependent manner from 50 pg kg<jats:sup>\u22121<\/jats:sup> to 50 ng kg<jats:sup>\u22121<\/jats:sup>.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p><jats:italic>N<\/jats:italic>\u2010methyl\u2010<jats:sc>D<\/jats:sc>\u2010aspartate (NMDA) receptor antagonists and Joro spider toxin, a Ca<jats:sup>2+<\/jats:sup>\u2010permeable AMPA receptor antagonist, inhibited the allodynia induced by ACRO\u2010A, but not by ACRO\u2010B. However, other AMPA\/kainate antagonists did not affect the allodynia induced by ACRO.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Whereas no neuronal damage was observed in the spinal cord in ACRO\u2010A\u2010treated mice, induction of allodynia by ACRO\u2010A (50 fg kg<jats:sup>\u22121<\/jats:sup>) and ACRO\u2010B (50 ng kg<jats:sup>\u22121<\/jats:sup>) was selectively lost 1 week after i.t. injection of a sublethal dose of ACRO\u2010A (50 ng kg<jats:sup>\u22121<\/jats:sup>) or ACRO\u2010B (250 ng kg<jats:sup>\u22121<\/jats:sup>). Higher doses of ACRO\u2010A, however, could evoke allodynia dose\u2010dependently from 50 pg kg<jats:sup>\u22121<\/jats:sup> to 500 ng kg<jats:sup>\u22121<\/jats:sup> in the ACRO\u2010A\u2010treated mice. The allodynia induced by ACRO\u2010A (500 ng kg<jats:sup>\u22121<\/jats:sup>) was not inhibited by Joro spider toxin or NMDA receptor antagonists. These properties of the late allodynia induced by ACRO\u2010A were quite similar to those of the acute allodynia induced by ACRO\u2010B.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>ACRO\u2010A could increase [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> in the deeper laminae, rather than in the superficial laminae, of the spinal cord. This increase was not blocked by the AMPA\u2010preferring antagonist GYKI52466 and Joro spider toxin.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Taken together, these results demonstrate the stereospecificity of ACRO for the induction of allodynia and suggest the presence of a receptor specific to ACRO.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2004) <jats:bold>142<\/jats:bold>, 679\u2013688. doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0705834\">10.1038\/sj.bjp.0705834<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0705834","type":"journal-article","created":{"date-parts":[[2004,6,17]],"date-time":"2004-06-17T17:18:11Z","timestamp":1087492691000},"page":"679-688","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Acute and late effects on induction of allodynia by acromelic acid, a mushroom poison related structurally to kainic acid"],"prefix":"10.1111","volume":"142","author":[{"given":"Toshiaki","family":"Minami","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Matsumura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikio","family":"Nishizawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Sasaguri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Hamanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1999.00691.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.2.726"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-06-02081.1999"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.17.030194.000335"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1991.tb12520.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-0102(01)00289-9"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)81571-3"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(92)90162-J"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(92)90870-D"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)01000-6"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(95)00076-E"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(93)90124-8"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)02069-8"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1999.00602.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01840.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1329206"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(94)90146-5"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)91685-5"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1992.tb14214.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199911260-00011"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200110000-00028"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1998.00048.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200009280-00030"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(95)00149-D"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(83)90201-4"}],"container-title":["British 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