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Suppressive effects were reversed by an increase of pHi with trimethylamine (TMA).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Using BCECF\u2010AM\u2010loaded slices, we found that LEV (10\u201350 <jats:italic>\u03bc<\/jats:italic><jats:sc>M<\/jats:sc>) reversibly lowered neuronal steady\u2010state pHi by 0.19\u00b10.07 pH units in the presence of extracellular CO<jats:sub>2<\/jats:sub>\/HCO<jats:sub>3<\/jats:sub><jats:sup>\u2212<\/jats:sup> buffer. In the nominal absence of extracellular CO<jats:sub>2<\/jats:sub>\/HCO<jats:sub>3<\/jats:sub><jats:sup>\u2212<\/jats:sup> or in Na<jats:sup>+<\/jats:sup>\u2010free CO<jats:sub>2<\/jats:sub>\/HCO<jats:sub>3<\/jats:sub><jats:sup>\u2212<\/jats:sup>\u2010buffered solution, LEV had no effect on steady\u2010state pHi.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Recovery of pHi subsequent to ammonium prepulses remained unchanged in the absence of CO<jats:sub>2<\/jats:sub>\/HCO<jats:sub>3<\/jats:sub><jats:sup>\u2212<\/jats:sup> buffer, but was significantly reduced by LEV in the presence of CO<jats:sub>2<\/jats:sub>\/HCO<jats:sub>3<\/jats:sub><jats:sup>\u2212<\/jats:sup> buffer. These findings show that LEV inhibits HCO<jats:sub>3<\/jats:sub><jats:sup>\u2212<\/jats:sup>\u2010dependent acid extrusion, but has no effect on Na<jats:sup>+<\/jats:sup>\/H<jats:sup>+<\/jats:sup> exchange.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>LEV did not affect Na<jats:sup>+<\/jats:sup>\u2010independent Cl<jats:sup>\u2212<\/jats:sup>\/HCO<jats:sub>3<\/jats:sub><jats:sup>\u2212<\/jats:sup> exchange because intracellular alkalosis upon withdrawal of extracellular Cl<jats:sup>\u2212<\/jats:sup> remained unchanged.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These data show that LEV at clinically relevant concentrations inhibits Na<jats:sup>+<\/jats:sup>\u2010dependent Cl<jats:sup>\u2212<\/jats:sup>\/HCO<jats:sub>3<\/jats:sub><jats:sup>\u2212<\/jats:sup> exchange, lowers neuronal pHi, and thereby may contribute to its anticonvulsive activity.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> 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