{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:44:20Z","timestamp":1791229460629,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,2,17]],"date-time":"2009-02-17T00:00:00Z","timestamp":1234828800000},"content-version":"vor","delay-in-days":1569,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>The concept that nitric oxide (NO) release can be beneficial in inflammatory conditions has raised more attention in the recent years, particularly with the development of nitric oxide\u2010releasing anti\u2010inflammatory drugs. There is considerable evidence that NO is capable of enhancing the anti\u2010inflammatory benefits of conventional anti\u2010inflammatory drugs.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Since hydrocortisone is the most widely used anti\u2010inflammatory drug for the treatment of skin inflammation, we compared the anti\u2010inflammatory effects of hydrocortisone to an NO\u2010releasing derivative of hydrocortisone, NCX 1022, in a murine model of irritant contact dermatitis, induced by epidermal application of benzalkonium chloride.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Topical pre\u2010 and post\u2010treatment with NCX 1022 (3 nmol) in C57BL6 mice not only reduced ear oedema formation in a dose\u2010dependent manner, but also was significantly more effective than the parent compound during the initial stages of inflammation (from 1 to 5 h). NCX 1022, but not hydrocortisone, significantly inhibited granulocyte recruitment (tissue myeloperoxidase activity). Histological samples of mouse ears treated with NCX 1022 showed significant reduction in both the number of infiltrated cells and disruption of the tissue architecture compared to hydrocortisone\u2010treated tissues.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>With intravital microscopy, we observed that both pre\u2010 and post\u2010treatments with NCX 1022 were more effective than hydrocortisone in terms of inhibiting benzalkonium chloride\u2010induced leukocyte adhesion to the endothelium, without affecting the flux of rolling leukocytes or venule diameter.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These results suggest that by releasing NO, NCX 1022 modulates one of the early events of skin inflammation: the recruitment of leukocytes to the site of inflammation. Overall, we have shown that NO\u2010hydrocortisone provided faster and greater protective effects, reducing major inflammatory parameters (leukocyte adhesion and recruitment, oedema formation, tissue disruption) compared to its parental compound.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2004) <jats:bold>143<\/jats:bold>, 618\u2013625. doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0705854\">10.1038\/sj.bjp.0705854<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0705854","type":"journal-article","created":{"date-parts":[[2004,10,28]],"date-time":"2004-10-28T22:33:50Z","timestamp":1099002830000},"page":"618-625","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Anti\u2010inflammatory effects of nitric oxide\u2010releasing hydrocortisone NCX 1022, in a murine model of contact dermatitis"],"prefix":"10.1111","volume":"143","author":[{"given":"Eric","family":"Hyun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manlio","family":"Bolla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Steinhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John L","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero","family":"Del Soldato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Vergnolle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,2,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1993.152"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/09629359891126"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000178955"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-2760(00)00325-8"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb04080.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64466-5"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.58.2.196"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/154.2_Pt_2.S11"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.105.4.794"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.2.318"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s000110050310"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.4049\/jimmunol.162.2.1137","article-title":"Varying roles of E\u2010selectin and P\u2010selectin in different microvascular beds in response to antigen","volume":"162","author":"HICKEY M.J.","year":"1999","journal-title":"J. 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