{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T06:14:50Z","timestamp":1767852890932,"version":"3.49.0"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":1430,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Pre\u2010eclampsia is a serious pregnancy disorder associated with widespread activation of the maternal vascular endothelium. Recent evidence implicates a role for oxidative stress in the aetiology of this condition.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Reactive oxygen species, particularly superoxide anions, invokes endothelial cell activation through many pathways. Oxidant\u2010induced cell injury triggers the activation of nuclear enzyme poly(ADP\u2010ribose) polymerase (PARP) leading to endothelial dysfunction in various pathophysiological conditions (reperfusion, shock, diabetes).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>We have studied whether the loss of endothelial function in pre\u2010eclampsia is dependent on PARP activity. Endothelium\u2010dependent responses of myometrial arteries were tested following exposure to either plasma from women with pre\u2010eclampsia or normal pregnant women in the presence and absence of a novel potent inhibitor of PARP, PJ34. Additional effects of plasma and PJ34 inhibition were identified in microvascular endothelial cell cultures.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In myometrial arteries, PARP inhibition blocked the attenuation of endothelium\u2010dependent responses following exposure to plasma from women with pre\u2010eclampsia. In endothelial cell cultures, plasma from pre\u2010eclamptics induced measurable oxidative stress and a concomitant increase in PARP activity and reduction in cellular ATP. Again, these biochemical changes were reversed by PJ34.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These results suggest that PARP activity plays a pathogenic role in the development of endothelial dysfunction in pre\u2010eclampsia and promotes PARP inhibition as a potential therapy in this condition.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2005) <jats:bold>144<\/jats:bold>, 772\u2013780. doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0706055\">10.1038\/sj.bjp.0706055<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0706055","type":"journal-article","created":{"date-parts":[[2005,1,17]],"date-time":"2005-01-17T18:25:43Z","timestamp":1105986343000},"page":"772-780","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Excessive stimulation of poly(ADP\u2010ribosyl)ation contributes to endothelial dysfunction in pre\u2010eclampsia"],"prefix":"10.1111","volume":"144","author":[{"given":"Ian P","family":"Crocker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise C","family":"Kenny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayne A","family":"Thornton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Csaba","family":"Szabo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip N","family":"Baker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(02)00844-1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1997.tb10939.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1998.tb10134.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.26.2.244"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0910711"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1996.271.5.C1424"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/6535"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(73)90094-8"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/jmf.12.1.28.34"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1997.tb00222.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1016254"},{"key":"e_1_2_7_13_1","article-title":"NOS expression is increased in endothelial cells exposed to plasma from women with preeclampsia","volume":"269","author":"DAVIDGE S.T.","year":"1995","journal-title":"Am. 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