{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T13:16:01Z","timestamp":1771074961256,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":1489,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Minocycline has anti\u2010inflammatory and antiapoptotic effects on cartilage, neurons and periodontal tissues, and both properties are central to the pharmaceutical treatment of liver diseases. We investigated the effects of minocycline on fulminant hepatitis in C57BL\/6J mice induced by lethal challenge of the activating anti\u2010Fas antibody, Jo2.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Intraperitoneal injection of Jo2 (0.6\u2003<jats:italic>\u03bc<\/jats:italic>g\u2003g<jats:sup>\u22121<\/jats:sup>) to mice resulted in fulminant hepatitis, as evidenced by increase of serum alanine\/aspartate transaminase activities and histopathological alterations in liver sections, as well as animal death. Nevertheless, mice pretreated with three doses of minocycline (5\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>) resisted this lethal effect significantly. Minocycline treatment improved the survival kinetics, although to a lesser extent, when mice were challenged simultaneously with Jo2 or even treated 30\u2003min after the lethal challenge.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Jo2\u2010induced activation of caspase\u20103 or \u20109 in liver tissues was inhibited by minocycline pretreatment, and yet the direct addition of minocycline to liver extracts from Jo2\u2010challenged mice failed to block caspase activation <jats:italic>in vitro<\/jats:italic>. Moreover, minocycline efficiently suppressed the release of cytochrome <jats:italic>c<\/jats:italic> from mitochondria of the liver tissues from Jo2\u2010challenged mice. In contrast, caspase\u20108 activation and Bid truncation triggered by Jo2 were not diminished by minocycline pretreatment in mouse livers.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Our results suggest that easing of Fas\u2010triggered fulminant hepatitis by minocycline may involve a mitochondrial apoptotic pathway, probably through preventing cytochrome <jats:italic>c<\/jats:italic> release and thereby blocking downstream caspase activation.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2005) <jats:bold>144<\/jats:bold>, 275\u2013282. doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0706079\">10.1038\/sj.bjp.0706079<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0706079","type":"journal-article","created":{"date-parts":[[2005,1,17]],"date-time":"2005-01-17T18:25:43Z","timestamp":1105986343000},"page":"275-282","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Effects of minocycline on Fas\u2010mediated fulminant hepatitis in mice"],"prefix":"10.1111","volume":"144","author":[{"given":"Heng\u2010Cheng","family":"Chu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Ling","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huey\u2010Kang","family":"Sytwu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin\u2010Hua","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching\u2010Len","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"You\u2010Chen","family":"Chao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.24.14014"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5381.1305"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.46.1.181"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/58.1.109"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.35.7.1434"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9861(02)00723-3"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/77528"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.251341998"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510310318"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.182.5.1223"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1985.56.11s.93"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.312.7024.169"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5381.1309"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)30039-6"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0196-80"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200023040-00006"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81590-1"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(02)02442-6"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80434-1"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81589-5"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.29590"},{"key":"e_1_2_7_23_1","first-page":"1641","article-title":"Minocycline\u2010induced liver injury","volume":"91","author":"MALCOLM A.","year":"1996","journal-title":"Am. 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