{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:38:15Z","timestamp":1790987895675,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,1,30]],"date-time":"2009-01-30T00:00:00Z","timestamp":1233273600000},"content-version":"vor","delay-in-days":1247,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>3,4\u2010Methylenedioxymethamphetamine (MDMA, \u2018ecstasy\u2019) administration to rats produces hyperthermia if they are housed in normal or warm ambient room temperature (<jats:italic>T<\/jats:italic><jats:sub>a<\/jats:sub>) conditions (20\u00b0C), but hypothermia when in cool conditions (<jats:italic>T<\/jats:italic><jats:sub>a<\/jats:sub>17\u00b0C). We have now investigated some of the mechanisms involved.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>MDMA (5\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup> i.p.) produced a rapid decrease in rectal temperature in rats at <jats:italic>T<\/jats:italic><jats:sub>a<\/jats:sub> 15\u00b0C. This response was blocked by pretreatment with the dopamine D<jats:sub>2<\/jats:sub> receptor antagonist remoxipride (10\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup> i.p.), but unaltered by pretreatment with the D<jats:sub>1<\/jats:sub> antagonist SCH23390 (1.1\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup> i.p.).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>MDMA (5\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>) did not alter the tail temperature of rats at <jats:italic>T<\/jats:italic><jats:sub>a<\/jats:sub> 15\u00b0C, but decreased the tail temperature of rats at <jats:italic>T<\/jats:italic><jats:sub>a<\/jats:sub> 30\u00b0C.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>A neurotoxic dose of MDMA (three doses of 5\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup> given 3\u2003h apart) decreased cortical and hippocampal 5\u2010HT content by approximately 30% 7 days later. This lesion did not influence the rise in tail temperature when rats were moved from <jats:italic>T<\/jats:italic><jats:sub>a<\/jats:sub> 20\u00b0C to 30\u00b0C compared to nonlesioned controls, but did result in a lower tail temperature than that of controls when they were returned to <jats:italic>T<\/jats:italic><jats:sub>a<\/jats:sub> 24\u00b0C.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Acute administration of MDMA (5\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>) to MDMA\u2010lesioned rats produced a sustained decrease in tail temperature in rats housed at <jats:italic>T<\/jats:italic><jats:sub>a<\/jats:sub> 30\u00b0C compared to nonlesioned controls.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>These data suggest that the thermoregulatory problems previously observed in MDMA\u2010lesioned rats housed at <jats:italic>T<\/jats:italic><jats:sub>a<\/jats:sub> 30\u00b0C result, partially, from their inability to lose heat by vasodilation of the tail, a major heat\u2010loss organ in this species.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2005) <jats:bold>146<\/jats:bold>, 306\u2013312. doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0706318\">10.1038\/sj.bjp.0706318<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0706318","type":"journal-article","created":{"date-parts":[[2005,7,4]],"date-time":"2005-07-04T15:46:28Z","timestamp":1120491988000},"page":"306-312","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Studies on the effect of MDMA (\u2018ecstasy\u2019) on the body temperature of rats housed at different ambient room temperatures"],"prefix":"10.1111","volume":"146","author":[{"given":"A Richard","family":"Green","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"O'Shea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn S","family":"Saadat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Martin","family":"Elliott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Isabel","family":"Colado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(79)90153-2"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701213"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-004-1788-8"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(76)90351-6"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02249342"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(95)00136-7"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050664"},{"key":"e_1_2_6_9_1","first-page":"644","article-title":"Effects of 3,4\u2010methylenedioxymethamphetamine on autonomic thermoregulatory responses of the rat","volume":"14","author":"GORDON C.J.","year":"1991","journal-title":"Pharmacol. 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