{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T23:15:19Z","timestamp":1773875719642,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,1,30]],"date-time":"2009-01-30T00:00:00Z","timestamp":1233273600000},"content-version":"vor","delay-in-days":1247,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:p>\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Reperfusion of an ischaemic tissue is associated with an intense inflammatory response and inflammation\u2010mediated tissue injury. Physalins, a group of substances with secosteroidal chemical structure, are found in <jats:italic>Physalis angulata<\/jats:italic> stems and leaves. Here, we assessed the effects of physalins on the local, remote and systemic injuries following intestinal ischaemia and reperfusion (I\/R) in mice and compared with the effects of dexamethasone.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Following I\/R injury, dexamethasone (10\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>) or physalin B or F markedly prevented neutrophil influx, the increase in vascular permeability in the intestine and the lungs. Maximal inhibition occurred at 20\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>. Moreover, there was prevention of haemorrhage in the intestine of reperfused animals.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Dexamethasone or physalins effectively suppressed the increase in tissue (intestine and lungs) and serum concentrations of TNF\u2010<jats:italic>\u03b1<\/jats:italic>. Interestingly, treatment with the compounds was associated with enhancement of IL\u201010.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The anti\u2010inflammatory effects of dexamethasone or physalins were reversed by pretreatment with the corticoid receptor antagonist RU486 (25\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>). The drug compounds suppressed steady\u2010state concentrations of corticosterone, but did not alter the reperfusion\u2010associated increase in levels of corticosterone. The IL\u201010\u2010enhancing effects of the drugs were not altered by RU486.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In conclusion, the <jats:italic>in vivo<\/jats:italic> anti\u2010inflammatory actions of physalins, natural steroidal compounds, appear to be mostly due to the activation of glucocorticoid receptors. Compounds derived from these natural secosteroids may represent novel therapeutic options for the treatment of inflammatory diseases.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2005) <jats:bold>146<\/jats:bold>, 244\u2013251. doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0706321\">10.1038\/sj.bjp.0706321<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0706321","type":"journal-article","created":{"date-parts":[[2005,7,11]],"date-time":"2005-07-11T09:57:17Z","timestamp":1121075837000},"page":"244-251","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":82,"title":["Mechanisms of the anti\u2010inflammatory effects of the natural secosteroids physalins in a model of intestinal ischaemia and reperfusion injury"],"prefix":"10.1111","volume":"146","author":[{"given":"Ang\u00e9lica T","family":"Vieira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Pinho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucilia B","family":"Lepsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Crist\u00f3foro","family":"Scavone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivone M","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Therezinha","family":"Tomassini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Ribeiro\u2010dos\u2010Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milena B P","family":"Soares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro M","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle G","family":"Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.60.5.563"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.10.3979"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0940557"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(89)90521-9"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/6.3.225"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(200002)190:3<255::AID-PATH526>3.0.CO;2-6"},{"key":"e_1_2_7_8_1","first-page":"155","article-title":"Inhibitory effects of physalin B and physalin F on various human leukemia cells in vitro","volume":"12","author":"CHIANG H.C.","year":"1992","journal-title":"Anticancer Res."},{"key":"e_1_2_7_9_1","first-page":"837","article-title":"Antitumor agent, physalin F from Physalis angulata L","volume":"12","author":"CHIANG H.C.","year":"1992","journal-title":"Anticancer Res."},{"key":"e_1_2_7_10_1","first-page":"223","article-title":"Effects of ischemia\u2013reperfusion injury on microvascular permeability in skeletal muscle","volume":"5","author":"DURAN W.N.","year":"1989","journal-title":"Microcirc. Endothelium Lymphatics"},{"key":"e_1_2_7_11_1","first-page":"III36","article-title":"Steroid\u2010induced myocardial preservation is associated with decreased cell membrane microviscosity","volume":"80","author":"ENGELMAN R.M.","year":"1989","journal-title":"Circulation"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(02)02959-X"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(97)00262-2"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1549-8719.1999.tb00099.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0502-473"},{"key":"e_1_2_7_16_1","first-page":"15","article-title":"Glucocorticoids inhibit the induction of nitric oxide synthase II by down\u2010regulating cytokine\u2010induced activity of transcription factor nuclear factor\u2010kappa B","volume":"49","author":"KLEINERT H.","year":"1996","journal-title":"Mol. Pharmacol."},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(90)90397-4"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2752(1996)17:9<495::AID-MICR4>3.0.CO;2-C"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X92000242"},{"key":"e_1_2_7_20_1","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S0008-6363(96)00073-9","article-title":"The role of nitric oxide and cell adhesion molecules on the microcirculation in ischaemia\u2013reperfusion","volume":"32","author":"LEFER A.M.","year":"1996","journal-title":"Cardiovasc. Res."},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.32.6.1083"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.20.4.435"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.8.2891"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2004.01824.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703704"},{"key":"e_1_2_7_26_1","doi-asserted-by":"crossref","first-page":"992","DOI":"10.4049\/jimmunol.150.3.992","article-title":"Modulation of IL\u20101\u2010induced neutrophil migration by dexamethasone and lipocortin 1","volume":"150","author":"PERRETTI M.","year":"1993","journal-title":"J. Immunol."},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.158.10.5007"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(03)00348-3"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)91176-F"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(02)02829-7"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703756"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704336"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00574-4"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.9.4759"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.4.2542"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705200"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705296"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)61122-4"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-003-2001-y"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(96)80217-0"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(01)00658-X"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118421"},{"key":"e_1_2_7_43_1","first-page":"821","article-title":"Endogenous glucocorticoids inhibit neutrophil recruitment to inflammatory sites in cholestatic rats","volume":"270","author":"TJANDRA K.","year":"1996","journal-title":"Am. J. Physiol."},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705324"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2004.01.008"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-3589(08)60074-5"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.bjp.0706321","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fsj.bjp.0706321","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/sj.bjp.0706321","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T21:29:52Z","timestamp":1697146192000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1038\/sj.bjp.0706321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["10.1038\/sj.bjp.0706321"],"URL":"https:\/\/doi.org\/10.1038\/sj.bjp.0706321","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,9]]},"assertion":[{"value":"2009-01-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}