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Oedema was measured at two time points, 2 and 4\u2003h, after intraplantar injection of carrageenan to anaesthetised mice.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Intraperitoneal (i.p.) injections of the FAAH inhibitor URB597 (0.1, 0.3, 1 and 3\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>) 30\u2003min prior to carrageenan administration, dose\u2010dependently reduced oedema formation. At the 4\u2003h time point, the ED<jats:sub>50<\/jats:sub> for URB597 was \u223c0.3\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>. Indomethacin (5\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>\u2003i.p.) completely prevented the oedema response to carrageenan.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The antioedema effects of indomethacin and URB597 were blocked by 3\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>\u2003i.p. of the CB<jats:sub>2<\/jats:sub> receptor antagonist SR144528. The effect of URB597 was not affected by pretreatment with the peroxisome proliferator\u2010activated receptor <jats:italic>\u03b3<\/jats:italic> antagonist bisphenol A diglycidyl ether (30\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>\u2003i.p.) or the TRPV1 antagonist capsazepine (10\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>\u2003i.p.), when oedema was assessed 4\u2003h after carrageenan administration. The CB<jats:sub>1<\/jats:sub> receptor antagonists AM251 (3\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup> i.p.) and rimonabant (0.5\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>\u2003i.p.) gave inconsistent effects upon the antioedema effect of URB597.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>FAAH measurements were conducted <jats:italic>ex vivo<\/jats:italic> in the paws, spinal cords and brains of the mice. The activities of FAAH in the paws and spinal cords of the inflamed vehicle\u2010treated mice were significantly lower than the corresponding activities in the noninflamed mice. PMSF treatment almost completely inhibited the FAAH activity in all three tissues, as did the highest dose of URB597 (3\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>) in spinal cord samples, whereas no obvious changes were seen <jats:italic>ex vivo<\/jats:italic> for the other treatments.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In conclusion, the results show that in mice, treatment with indomethacin and URB597 produce SR144528\u2010sensitive anti\u2010inflammatory effects in the carrageenan model of acute inflammation.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2005) <jats:bold>146<\/jats:bold>, 467\u2013476. doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0706348\">10.1038\/sj.bjp.0706348<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0706348","type":"journal-article","created":{"date-parts":[[2005,8,15]],"date-time":"2005-08-15T04:41:55Z","timestamp":1124080915000},"page":"467-476","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":142,"title":["Inhibitors of fatty acid amide hydrolase reduce carrageenan\u2010induced hind paw inflammation in pentobarbital\u2010treated mice: comparison with indomethacin and possible involvement of cannabinoid receptors"],"prefix":"10.1111","volume":"146","author":[{"given":"Sandra","family":"Holt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Comelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J","family":"Fowler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2003.02470.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jms.729"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00184.2004"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.02244.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00226-0"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-1754fje"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1096\/fj.02-1075fje","article-title":"PPAR\u03b3 ligands induce prostaglandin production in vascular smooth muscle cells: indomethacin acts as a peroxisome proliferator\u2010activated receptor\u2010\u03b3 antagonist","volume":"17","author":"BISHOP\u2010BAILEY D.","year":"2003","journal-title":"FASEB J."},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2005.01.027"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbbm.2004.04.020"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(01)00454-7"},{"key":"e_1_2_7_12_1","first-page":"1138","article-title":"The effect of the enzyme inhibitor phenylmethylsulfonyl fluoride on the pharmacological effect of anandamide in the mouse model of cannabimimetic activity","volume":"283","author":"COMPTON D.R.","year":"1997","journal-title":"J. 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