{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T22:25:35Z","timestamp":1776032735829,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":1124,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:p><jats:list list-type=\"explicit-label\"><jats:list-item><jats:p>4\u2010methyl benzylamine (4\u2010MBZ; 28\u2003<jats:italic>\u03bc<\/jats:italic>g, 231\u2003nmol) elicits a hyperphagic response in starved mice in contrast to the hypophagia induced by the parent compound benzylamine (BZ; 33\u2003<jats:italic>\u03bc<\/jats:italic>g, 231\u2003nmol) or by amphetamine (AMPH, 2\u2003<jats:italic>\u03bc<\/jats:italic>g).<\/jats:p><\/jats:list-item><jats:list-item><jats:p>In mice starved for only 4\u2003h, and therefore with little stimulation to eat, the maximal increase in food consumption induced by intracerebroventricular (i.c.v.)\u2010injected 4\u2010MBZ was 190% over that of the controls (ED<jats:sub>50<\/jats:sub>8.3\u00b12.7\u2003<jats:italic>\u03bc<\/jats:italic>g\u2003mouse<jats:sup>\u22121<\/jats:sup>; 68\u00b122\u2003nmol\u2003mouse<jats:sup>\u22121<\/jats:sup>), whereas after i.p. administration, these values were 160% and approximately 129\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, respectively.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>The hyperphagic effect of 4\u2010MBZ was reduced by more than 60% in mice pretreated with antisense oligodeoxyribonucleotide (aODN<jats:sub>1<\/jats:sub>) previously found to selectively inhibit (over 50%) the expression of<jats:italic>Shaker\u2010like<\/jats:italic>Kv1.1 channels.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>In mice highly stimulated to eat after 12\u2010h fasting, 4\u2010MBZ (28\u2003<jats:italic>\u03bc<\/jats:italic>g) significantly reduced (to about 70%) the hypophagic response by AMPH (2\u2003<jats:italic>\u03bc<\/jats:italic>g) or BZ (33\u2003<jats:italic>\u03bc<\/jats:italic>g). Conversely, these two compounds reduced (respectively, by 69 and 44%) the hyperphagic response of 4\u2010MBZ in 4\u2010h fasting mice.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>4\u2010MBZ (28\u2003<jats:italic>\u03bc<\/jats:italic>g) also reduced the hypermotility and the stimulation of inspection activity elicited by AMPH in mice and the release of DA stimulated by AMPH (2\u2003<jats:italic>\u03bc<\/jats:italic>g) from the nucleus accumbens of rats.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>We hypothesize that 4\u2010MBZ elicits hyperphagic effects probably by opening<jats:italic>Shaker\u2010like<\/jats:italic>Kv1.1 subtypes in the brain, whereas AMPH and BZ are hypophagic by blocking these channels.<\/jats:p><\/jats:list-item><\/jats:list><\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic>(2006)<jats:bold>147<\/jats:bold>, 218\u2013224. doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/sj.bjp.0706465\">10.1038\/sj.bjp.0706465<\/jats:ext-link><\/jats:p>","DOI":"10.1038\/sj.bjp.0706465","type":"journal-article","created":{"date-parts":[[2005,11,14]],"date-time":"2005-11-14T11:40:15Z","timestamp":1131968415000},"page":"218-224","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["4\u2010methyl benzylamine stimulates food consumption and counteracts the hypophagic effects of amphetamine acting on brain<i>Shaker\u2010like<\/i>Kv1.1 channels"],"prefix":"10.1111","volume":"147","author":[{"given":"Renato","family":"Pirisino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicoletta","family":"Galeotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Livi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Raimondi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Ghelardini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(01)00739-7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/phrs.1999.0571"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevNeurobiol.v12.i1-2.30"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2396(200005)36:2<102::AID-SYN3>3.0.CO;2-#"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1991.tb03485.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-200009000-00016"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2305265"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn0901-873"},{"key":"e_1_2_8_10_1","first-page":"181","volume-title":"Potassium Channels: Structure, Classification, Function and Therapeutic Potential","author":"COOK N.S.","year":"1990"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1995.tb15133.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(97)10134-0"},{"key":"e_1_2_8_13_1","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/S0022-3565(24)36646-7","article-title":"An antisense oligonucleotide on the mouse Shaker\u2010like potassium channel Kv1.1 gene prevents antinociception induced by morphine and baclofen","volume":"281","author":"GALEOTTI N.","year":"1997","journal-title":"J. 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